Observations on delta homeostasis, the one-stimulus model of NREM-REM alternation and the neurobiologic implications of experimental dream studies

Behavioural Brain Research
I Feinberg, J D March

Abstract

We first review the concept of delta homeostasis as formulated in our 1974 model and as developed quantitatively by Borbely and colleagues in several versions of the two-process model. We illustrate difficulties in the application of this quantitative model to the negative delta rebound in the rat and we put forward additional evidence that the negative rebound is a pathological rather than a homeostatic response to sleep deprivation. We next review experiments on rats in which the waking metabolic rate of limbic structures was increased by blockade of the NMDA-gated cation channel with ketamine and MK-801. As predicted by the 1974 homeostatic model, NREM delta increased during subsequent sleep. However, it remains to be shown that this powerful effect is actually caused by the metabolic change and that it is an intensification of physiological sleep rather than a non-specific increase in EEG slow waves caused by neurotoxicity. We then outline our one-stimulus model of NREM/REM alternation. In this model NREM sleep is induced by periodic (neuroendocrine?) pulses. These pulses increase delta EEG amplitude and density, depress arousal level and inhibit neural activity. When the strength of the pulsatile stimulus falls below a cri...Continue Reading

References

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Citations

Oct 25, 2008·Psychopharmacology·Mark BlagroveBrigitte Brandner
Jul 1, 1995·Behavioural Brain Research·A GiudittaS Vescia
May 15, 2013·European Journal of Pharmacology·Ana M ValentimLuís M Antunes
Dec 6, 2000·Journal of Psychiatric Research·L PalaginiI Feinberg
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·I FeinbergK Anderson
Feb 1, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tomoka TakeuchiAnthony V Ferrelli
Feb 24, 2001·Journal of Psychoactive Drugs·K L Jansen
Oct 12, 2010·Schizophrenia Bulletin·Irwin Feinberg
Nov 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Irwin FeinbergIan G Campbell
Jun 1, 2012·Consciousness and Cognition·Delphine OudietteIsabelle Arnulf
Nov 17, 2009·Brain and Cognition·Sidney J SegalowitzMichelle K Jetha
Dec 24, 2004·Journal of Theoretical Biology·Amir Muzur
Jul 13, 2004·Brain Research Bulletin·Laura PalaginiIan G Campbell
Dec 9, 2004·Neurobiology of Aging·Ian G Campbell, Irwin Feinberg
Apr 18, 1998·Electroencephalography and Clinical Neurophysiology·I Fagioli, P Salzarulo
Aug 17, 1999·The British Journal of Psychiatry : the Journal of Mental Science·I Feinberg, M Guazzelli
Jun 27, 2020·The European Journal of Neuroscience·Yujun WenJun Lu
Feb 20, 2021·Neurobiology of Sleep and Circadian Rhythms·Marcos G Frank

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