PMID: 737094Dec 1, 1978Paper

Observations on intravenous administration of lignocaine in patients with myocardial infarction

British Heart Journal
N P CampbellJ F Pantridge

Abstract

Lignocaine was administered intravenously to 36 patients with acute myocardial infarction. A bolus of 100 mg followed by an infusion of 2 mg/minute failed to maintain plasma levels above 2 microgram/ml. A bolus of 100 mg followed by 4 mg/minute also failed to maintain satisfactory plasma concentrations during the first hour of therapy. A bolus of 75 mg was combined with an infusion of 10 mg/minute for 20 minutes followed by 1.5 mg/minute. Satisfactory plasma concentrations during the first hour were observed in 94 per cent of the estimations. No important adverse side effects occurred during the infusion of 10 mg/minute.

References

Sep 1, 1977·British Heart Journal·R A LevyW J Mandel
Jul 19, 1976·JAMA : the Journal of the American Medical Association·D J GreenblattJ S Harmatz
Jan 1, 1975·Clinical Pharmacology and Therapeutics·E F EvansA J Wasserman
Jan 3, 1976·British Medical Journal·C ApsF Reynolds
Oct 1, 1974·Clinical Pharmacology and Therapeutics·J G Wagner
May 1, 1972·Archives of Internal Medicine·J Koch-Weser
Dec 1, 1974·Circulation·K A CollinsworthD C Harrison
Feb 1, 1974·Journal of Clinical Pharmacology·M L SchwartzP Kamp
Aug 1, 1974·American Heart Journal·J S GeddesA A Adgey
Aug 1, 1969·The American Journal of Cardiology·J I GrossmanJ Frieden

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Citations

Aug 22, 2015·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalShrikant Bangdiwala

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