Observations on seminal vesicle dynamics in an in vivo rat model

The Journal of Urology
P J TurekH T Nguyen

Abstract

To gain understanding of the seminal vesicle as a muscular organ, seminal vesicle compliance and contractile properties were quantified with an in vivo, microsurgical rat model. Microsurgical dissection was performed on anesthetized rats to enable simultaneous organ filling and monitoring of intraluminal pressures. The reliability and reproducibility of post-ganglionic hypogastric nerve-induced ipsilateral (4 rats) and bilateral (5 rats) seminal vesicle contractile responses were assessed during repeated nerve stimulation. Seminal vesicle resting compliance was assessed during a constant saline infusion (10 rats). Functional performance curves were obtained at fixed fill-volumes by measuring organ contraction after nerve stimulation (4 rats). A reproducible seminal vesicle contractile response was obtained with a nerve stimulation interval > 15 minutes. Bilateral seminal vesicle responses were observed with unilateral nerve stimulation. The resting organ compliance curve with saline filling exhibited a characteristic, triphasic response. Functional performance studies revealed that contractile performance improves as the fill-volume increases until the distensibility limit of the organ is reached. A reliable, in vivo, rat model...Continue Reading

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Citations

Jun 5, 2013·Current Urology Reports·Joseph W McQuaid, Cigdem Tanrikut
May 16, 2006·The Journal of Urology·Irfan OrhanAteş Kadioğlu
Dec 2, 2015·Nature Reviews. Urology·Vaibhav ModgilAsif Muneer
May 24, 2008·The Journal of Urology·Michael L EisenbergPaul J Turek
Apr 22, 2008·The Urologic Clinics of North America·James F SmithPaul J Turek
Dec 11, 2003·The Journal of Urology·Rajveer S PurohitPaul J Turek
Jun 14, 2001·The Urologic Clinics of North America·V A Master, P J Turek
Jun 22, 2007·Biology of Reproduction·Jacques BernabéFrançois Giuliano
Sep 14, 2007·Archives of Andrology·Mehmet Ruhi OnurErcan Kocakoç
Jan 11, 2002·Journal of Andrology·Jae-Seog HyunWayne J G Hellstrom

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