PMID: 6977620Nov 1, 1981Paper

Observations on the effects of low frequency electrical stimulation on fast muscles of dystrophic mice

Journal of Neurology, Neurosurgery, and Psychiatry
G Vrbová, K M Ward

Abstract

The deterioration of tibialis anterior (TA) and extensor digitorum longus (EDL) muscles in dystrophic mice (C 57 BL dy/dy) was compared. The effects of chronic electrical stimulation on various characteristic properties of these muscles were also studied. The results indicate that EDL muscles are less affected by the disease than TA. This "selectivity" is difficult to explain since both muscles have similar fibre type composition. TA and EDL muscles that were stimulated for 10-28 days developed greater tetanic tensions than the contralateral muscles, but this effect was apparent only when the muscles were severely affected by the disease, that is the contralateral TA or EDL muscles developed less than 50% of the tension produced by muscles from normal animals. In all EDL muscles, stimulation increased the fatigue resistance. The time course of contraction and relaxation of dystrophic muscles is usually slower than that of normal muscles. The stimulation reduced this slowing effect, so that the stimulated muscles became similar to homologous muscles from normal littermates.

References

Jun 8, 1977·Pflügers Archiv : European journal of physiology·O HudlickáG Vrbová
Feb 6, 1973·Pflügers Archiv : European journal of physiology·D PetteG Vrbová
Sep 1, 1981·Pflügers Archiv : European journal of physiology·W H Kwong, G Vrbová
Feb 1, 1981·The Journal of Physiology·P M NemethG Vrbová
Dec 1, 1980·The Journal of Physiology·Y Miyata, K Yoshioka
Sep 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·P LuthertK M Ward
Jul 1, 1957·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M NACHLASA M SELIGMAN
May 12, 1977·Nature·A Montgomery, L Swenarchuk

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Citations

Dec 1, 1986·Experimental Neurology·J Dangain, G Vrbová
Jul 1, 1988·Journal of the Neurological Sciences·P WirtzJ C Hendriks
Dec 1, 1988·Journal of the Neurological Sciences·J Dangain, G Vrbová
Sep 1, 1989·Journal of the Neurological Sciences·R J LaneE Jaros
Jul 8, 2008·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·P DehailM Barat
Dec 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J Dangain, G Vrbova
Dec 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·O M ScottV Dubowitz

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