PMID: 13939659Apr 1, 1963Paper

Observations on the isolated vas deferens

British Journal of Pharmacology and Chemotherapy


Experiments on the isolated vas deferens of guinea-pig and rat had unexpected results in several ways. The effect of stimulation of the hypogastric nerve was not abolished, but increased, by parasympathetic blocking agents or by sympathetic blocking agents such as dihydroergotamine and phenoxybenzamine. The sensitization is considered not due to anticholinesterase activity of the drugs. Prolonged contact with a stimulating agent evoked rhythmic contractions. Addition as well as removal of a drug from the bath caused a response. The results of experiments involving chronic denervation, addition of hexamethonium and histological examination tally with the assumption of a distribution of ganglionic cells along the nerve just outside the organ.


Jun 28, 1956·The Journal of Physiology·C O HEBB, G M WAITES
Mar 7, 1957·Acta Physiologica Scandinavica·N EMMELIN, B C STROMBLAD
Dec 15, 1958·Acta Physiologica Scandinavica·A BERTLERE ROSENGREN
Jan 1, 1961·The Journal of Physiology·G BURNSTOCK, M E HOLMAN
Apr 1, 1961·British Journal of Pharmacology and Chemotherapy·S HUKOVIC
Mar 1, 1962·The Journal of Physiology·G BURNSTOCK, M E HOLMAN
Mar 1, 1962·The Journal of Physiology·G BURNSTOCK, M E HOLMAN
Jan 1, 1963·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·I NORDENFELT
Dec 1, 1960·British Journal of Pharmacology and Chemotherapy·H BoydM J Rand

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