Observed Survival Interval: A Supplement to TCGA Pan-Cancer Clinical Data Resource

Cancers
Jie XiongShengyu Guo

Abstract

To drive high-quality omics translational research using The Cancer Genome Atlas (TCGA) data, a TCGA Pan-Cancer Clinical Data Resource was proposed. However, there is an out-of-step issue between clinical outcomes and the omics data of TCGA for skin cutaneous melanoma (SKCM), due to the majority of metastatic samples. In clinical cases, the survival time started from the initial SKCM diagnosis, while the omics data were characterized at TCGA sampling. This study aimed to address this issue by proposing an observed survival interval (OBS), which was defined as the time interval from TCGA sampling to patient death or last follow-up. We compared the OBS with the usual recommended overall survival (OS) by associating them with both clinical data and microRNA sequencing data of TCGA-SKCM. We found that the OS of primary SKCM was significantly shorter than that of metastatic SKCM, while the opposite happened if OBS was compared. OS was associated with the pathological stage of both primary and metastatic SKCM, while OBS was associated with the pathological stage of primary SKCM but not that of metastatic SKCM. Five previously cross-validated survival-associated microRNAs were found to be associated with the OBS rather than OS in meta...Continue Reading

References

Feb 4, 2010·Cancer Research·Xiaoxia HuXiaowei Wang
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Miguel F SeguraEva Hernando
Apr 2, 2010·The Journal of Investigative Dermatology·Stefano CaramutaWeng-Onn Lui
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Jun 20, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Doug HannifordEva Hernando
Jun 20, 2015·Cell·UNKNOWN Cancer Genome Atlas Network
Sep 1, 2013·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Z AliJ Larkin
Jan 15, 2016·The Journal of Investigative Dermatology·Kaushala JayawardanaJean Yang
Oct 14, 2017·CA: a Cancer Journal for Clinicians·Jeffrey E GershenwaldUNKNOWN for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Disc
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 14, 2018·International Journal of Oncology·Shuocheng YangXuan Zeng

❮ Previous
Next ❯

Citations

Sep 14, 2019·Cancer Cell International·Liwei WangZhiwen Chen
Apr 17, 2020·Frontiers in Bioengineering and Biotechnology·Yang ShengLiang Geyu
Oct 28, 2019·Cancers·Chad Brenner
Nov 17, 2020·Frontiers in Immunology·Ya-Nan XueWei-Qiang Tan
Mar 6, 2021·Frontiers in Molecular Biosciences·Zhengtong LvYuan Li
Oct 12, 2021·Frontiers in Molecular Biosciences·Ayşegül Kutlay, Yeşim Aydin Son

❮ Previous
Next ❯

Software Mentioned

survival
survminer
gPCA
TCGA
DESeq2
timeROC

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

La Revue du praticien
Marie-Françoise Avril
Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Julius MoratinChristian Linz
© 2022 Meta ULC. All rights reserved