Observed Treatment Responses to Short-Course Doxycycline Therapy for Rectal Lymphogranuloma Venereum in Men Who Have Sex With Men

Sexually Transmitted Diseases
Rebecca SimonsJ A White

Abstract

Lymphogranuloma venereum (LGV) has reestablished itself as an endemic sexually transmitted infection in the United Kingdom and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including its duration is very limited. We conducted a retrospective review in 2 central London genitourinary medicine clinics of men who have sex with men (MSM) with LGV in whom less than 21 days of doxycycline was used initially. Sixty MSM were treated initially with less than 21 days of doxycycline, of whom 50 (83%) were prescribed a 7-day course. Fifty percent of patients were asymptomatic, with the rest having rectal or other symptoms. Fifty-nine (97%) of 60 had a negative test of cure for LGV at a median of 31 days (7-200 days). Reinfection as opposed to treatment failure was considered likely in the patient testing positive. A second test of cure at a median of 139 days later (37-638 days) was completed in 30 patients, of whom 28 (93%) were negative for LGV. Seven to 14 days of doxycycline is effective in most cases of LGV with negative TOCs in 59 of 60 patients. These data suggest that 7 days of doxycycline is effective in achi...Continue Reading

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Citations

Jul 2, 2019·Sexually Transmitted Diseases·Francisco Galeano-ValleFrancisco Tejerina-Picado
Feb 1, 2020·Sexually Transmitted Diseases·H Hunter Handsfield, John A White
May 21, 2020·The New England Journal of Medicine·Deborah A Williamson, Marcus Y Chen
Apr 12, 2018·Sexually Transmitted Diseases·H Hunter Handsfield
Jun 28, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·H J C de VriesM Unemo
Jul 23, 2021·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Kimberly A WorkowskiGail A Bolan
Oct 12, 2021·Annals of Internal Medicine·Julia C Dombrowski
Jan 12, 2022·JAMA : the Journal of the American Medical Association·Susan TuddenhamKhalil G Ghanem

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