Observing Single Molecules Complexing with Cucurbit[7]uril through Nanogap Surface-Enhanced Raman Spectroscopy.

The Journal of Physical Chemistry Letters
Daniel O SigleOren A Scherman

Abstract

In recent years, single-molecule sensitivity achievable by surface-enhanced Raman spectroscopy (SERS) has been widely reported. We use this to investigate supramolecular host-guest chemistry with the macrocyclic host cucurbit[7]uril, on a few-to-single-molecule level. A nanogap geometry, comprising individual gold nanoparticles on a planar gold surface spaced by a single layer of molecules, gives intense SERS signals. Plasmonic coupling between the particle and the surface leads to strongly enhanced optical fields in the gap between them, with single-molecule sensitivity established using a modification of the well-known bianalyte method. Changes in the Raman modes of the host molecule are observed when single guests included inside its cavity internally stretch it. Anisotropic intermolecular interactions with the guest are found which show additional distinct features in the Raman modes of the host molecule.

References

Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hee-Joon KimKimoon Kim
Feb 14, 2004·The Journal of Organic Chemistry·Winston Ong, Angel E Kaifer
Dec 30, 2004·Angewandte Chemie·Rainer EckelDario Anselmetti
Nov 10, 2005·Journal of the American Chemical Society·Simin LiuLyle Isaacs
Jun 10, 2008·Chemical Communications : Chem Comm·Qi AnWeixia Zhang
Oct 8, 2009·Journal of the American Chemical Society·Evan J BlackiePablo G Etchegoin
Jun 29, 2010·Physical Chemistry Chemical Physics : PCCP·Sumeet MahajanOren A Scherman
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Wei-Hao HuangLyle Isaacs
Jan 26, 2011·Physical Chemistry Chemical Physics : PCCP·Pablo G EtchegoinA Fainstein
Aug 13, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Alberto Gomez-CasadoJurriaan Huskens
Dec 30, 2011·Analytical and Bioanalytical Chemistry·Dana CiallaJürgen Popp
Sep 1, 2012·Science·C CiracìD R Smith
Feb 6, 2013·Angewandte Chemie·Youngjoo AhnKimoon Kim
Mar 26, 2013·Physical Chemistry Chemical Physics : PCCP·Hae Mi LeeYung Doug Suh
Nov 7, 2013·Journal of Environmental Sciences (China)·Feihu YaoYunlong Fu
Aug 13, 2014·Scientific Reports·Richard W TaylorJeremy J Baumberg
Sep 6, 2014·Physical Review Letters·Daniel O SigleJeremy J Baumberg
Oct 31, 2014·Scientific Reports·Setu KaseraOren A Scherman
Apr 4, 2013·The Journal of Physical Chemistry Letters·Partha Pratim Patra, G V Pavan Kumar
Nov 14, 2015·Chemical Reviews·Steven J BarrowOren A Scherman

❮ Previous
Next ❯

Citations

Jun 24, 2017·Chemical Society Reviews·M Fernanda CardinalRichard P Van Duyne
Nov 7, 2017·Nanoscale·Addison R L MarshallAli M Adawi
Sep 22, 2017·Faraday Discussions·Bart de NijsOren A Scherman
Aug 4, 2018·Advanced Materials·Sivaraman SubramanianFrank Vollmer
Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Marlous KampJeremy J Baumberg
Jul 1, 2017·Chemical Society Reviews·Song-Yuan DingMartin Moskovits
Jul 29, 2017·Physical Review Letters·William M DeaconJeremy J Baumberg
Nov 27, 2020·Frontiers in Chemistry·Dénes BertaEdina Rosta
Apr 14, 2020·Chemical Science·Ana Isabel Pérez-JiménezBin Ren
Aug 2, 2017·ACS Sensors·Adam B Taylor, Peter Zijlstra
Jun 15, 2017·Chemical Reviews·Alyssa B ZrimsekRichard P Van Duyne
Oct 21, 2017·ACS Nano·William J ThriftRegina Ragan
Dec 10, 2021·ACS Sensors·David-Benjamin GrysJeremy J Baumberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved