PMID: 11607922Oct 19, 2001Paper

Obsessive compulsive disorder: is there an association with childhood streptococcal infections and altered immune function?

Seminars in Clinical Neuropsychiatry
T K MurphyW K Goodman

Abstract

During the last few years, an increased interest in the possibility of immune mediated pathophysiology of obsessive compulsive disorder (OCD) and related disorders has been seen. In the late 1980s, the National Institute of Mental Health reported an increase of obsessive compulsive symptoms in patients with Sydenham chorea (SC). Subsequently, a precipitating streptococcal infection in children with sudden onset of OCD symptoms but no chorea led to the coining of PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus). This association has furthered interest in studying immune parameters in non-PANDAS OCD as well. This article will review the neuropsychiatric findings in OCD and Tourette syndrome (TS) with emphasis placed on PANDAS, and its association with SC, and a review of the existing studies that have assessed immunologic measures in patients with OCD and TS.

Citations

Feb 28, 2006·British Journal of Hospital Medicine·Eva M Cybulska
Jul 13, 2004·Current Opinion in Neurology·Davide Martino, Gavin Giovannoni
Jan 1, 2011·Journal of Central Nervous System Disease·Alessandro S De NadaiTanya K Murphy
Jul 9, 2004·Molecular Psychiatry·L A Snider, S E Swedo
Apr 14, 2005·International Journal of Psychiatry in Medicine·Bernardus R Coetzer
Mar 6, 2003·Neurologic Clinics·William M McMahonJenise Jensen

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