Obsessive-Compulsive Disorder

Continuum : Lifelong Learning in Neurology
Peggy M A Richter, Renato T Ramos

Abstract

This article reviews current knowledge regarding diagnosis, pathophysiology, and treatment trends in obsessive-compulsive disorder (OCD), a severe, underrecognized, and chronic condition frequently encountered in neurologic practice. With a lifetime prevalence estimated at 2.5%, OCD is a common condition that can also present comorbidly with neurologic disease. The core symptoms of OCD are obsessions and compulsions. Obsessions are intrusive repetitive thoughts, urges, images, or impulses that trigger anxiety and that the individual is not able to suppress. Compulsions are repetitive behaviors or mental acts occurring in response to an obsession with the intention of reducing the distress caused by obsessions. Neuroimaging, neuropsychological, and pharmacologic studies suggest that the expression of OCD symptoms is associated with dysfunction in a cortico-striato-thalamo-cortical circuit. Evidence-based treatments for OCD comprise pharmacotherapy and cognitive-behavioral therapy. Selective serotonin reuptake inhibitors (SSRIs) are the first-line drugs recommended for OCD, but significant differences exist in their use for OCD compared to their use for other mood and anxiety conditions, including the need for higher dosage, long...Continue Reading

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Citations

Jun 1, 2018·Continuum : Lifelong Learning in Neurology·Peter Giacobbe, Alastair Flint
Nov 2, 2019·International Journal of Psychiatry in Clinical Practice·Marlene Taube-SchiffMargaret A Richter
Jan 8, 2020·Social Psychiatry and Psychiatric Epidemiology·Behrang MahjaniDorothy E Grice
Jul 25, 2021·International Journal of Environmental Research and Public Health·Wuqianhui LiuYuan He

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