Obsessive-compulsive spectrum disorders and rheumatic fever: a family study

Biological Psychiatry
Ana Gabriela HounieEurípedes Constantino Miguel

Abstract

Obsessive-compulsive spectrum disorders (OCSDs) are more frequent in patients with active or prior rheumatic fever (RF), suggesting that OCSD and RF may share underlying etiologic mechanisms. Our objective was to estimate the frequency of OCSD in first-degree relatives (FDRs) of RF patients and controls to determine whether there is a familial relationship between OCSD and RF. This is a case-control family study. Of the 98 probands included in this study, 31 had RF without Sydenham's chorea (SC) and had 131 relatives, 28 had RF with SC and had 120 relatives, and 39 were controls without RF. All probands, 87.9% of the RF FDRs and 93.7% of the control FDRs were assessed directly with structured psychiatric interviews and best-estimate diagnoses were assigned. Odds ratios of morbid risks were estimated using logistic regression by the generalized estimating equations (GEE) method and compared between groups. The rate of OCSDs was significantly higher among FDRs of RF probands than among FDRs of controls (n=37; 14.7% vs. n=10; 7.3%, i=.0279). A diagnosis of OCSDs in an RF proband was associated with a higher rate of OCSDs among FDRs when compared to control FDRs (p-GEE=.02). There was a trend for a higher rate of OCSDs among FDRs o...Continue Reading

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Citations

May 1, 2015·Developmental Medicine and Child Neurology·Mallika PunukolluMichael Morton
Feb 4, 2012·Comprehensive Psychiatry·Leonardo F FontenelleAntonio Lucio Teixeira
Jun 9, 2009·Seminars in Pediatric Neurology·Donald L Gilbert
Jun 27, 2009·Neurologic Clinics·Francisco Cardoso
Mar 10, 2009·General Hospital Psychiatry·Pedro Gomes de AlvarengaEurípedes C Miguel
May 5, 2009·General Hospital Psychiatry·Aline S SampaioAna G Hounie
Sep 29, 2011·Developmental Medicine and Child Neurology·Hilla Ben-PaziRuth S Shalev
Oct 6, 2009·Psychiatry Research·Ygor Arzeno FerrãoDan Joseph Stein
Jan 15, 2013·Neuroscience and Biobehavioral Reviews·Mady Hornig, W Ian Lipkin
Jul 22, 2008·Neuroscience Letters·Ana Gabriela HounieEurípedes Constantino Miguel
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Ana Pérez-VigilDavid Mataix-Cols
Jul 7, 2009·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Quirino CordeiroAna Gabriela Hounie
Jul 7, 2009·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Quirino CordeiroMarco Aurélio Romano-Silva
Oct 30, 2013·Therapeutic Advances in Psychopharmacology·Görkem Karakaş UğurluAli Cayköylü
Nov 17, 2019·International Journal of Environmental Research and Public Health·Michael G BakerDiana Lennon
May 22, 2007·CNS Spectrums·Naomi A FinebergKevin J Craig
Jan 31, 2009·CNS Spectrums·A Augusto Anderson SeixasEurípedes C Miguel
Jul 3, 2021·International Journal of Environmental Research and Public Health·Yi-Jung ChangJames Cheng-Chung Wei
Nov 4, 2008·Pediatrics·Pedro Gomes de AlvarengaEurípedes C Miguel

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