Obsessive-compulsive symptoms associated with clozapine and risperidone treatment: three case reports and review of the literature

The Kaohsiung Journal of Medical Sciences
Chiao-Li KeMing-Jen Yang

Abstract

Treatment-emergent obsessive-compulsive symptoms (OCSs) have raised concern since the widespread introduction of serotonin-dopamine antagonists (SDAs) for the treatment of schizophrenia. Further investigations of SDA-emergent OCSs and their response to anti-obsessional agents will be beneficial for clinicians in helping patients who suffer from this problem. We present three cases of schizophrenia in which distressing OCSs occurred during clozapine or risperidone treatment. OCSs were assessed consecutively using the Yale-Brown Obsessive-Compulsive Scale. The OCSs of these three patients were responsive to anti-obsessional agents, including fluvoxamine, clomipramine, and paroxetine. We also review the current literature and discuss the possible pathophysiology and psychopathology of SDA-emergent OCSs.

References

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Citations

May 11, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elliot HadiPinkhas Sirota
May 24, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Joo Hyun KimKyung Sue Hong
May 6, 2016·Expert Opinion on Pharmacotherapy·Massimiliano BuoliA Carlo Altamura
Jan 31, 2021·Medical Hypotheses·David D KimRic M Procyshyn

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