Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis.

Diabetologia
K AndralojcM Gotthardt

Abstract

For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evaluation. To many diabetologists it may remain unclear why the imaging world struggles to develop an effective method for non-invasive beta cell imaging (BCI), which could be useful for both research and clinical purposes. Here, we provide a concise overview of the obstacles and challenges encountered on the way to such BCI, in both native and transplanted islets. We discuss the major difficulties posed by the anatomical and cell biological features of pancreatic islets, as well as the chemical and physical limits of the main imaging modalities, with special focus on PET, SPECT and MRI. We conclude by indicating new avenues for future research in the field, based on several remarkable recent results.

References

Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M SheppardM Gregory
Apr 1, 1988·Transplantation·Z A LatifR Alejandro
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H BernardiM Lazdunski
Jan 1, 1996·Digestion·E P KrenningD J Kwekkeboom
Sep 24, 1998·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·P GarnuszekA P Mazurek
Apr 5, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Wouter A P BreemanEric P Krenning
Jul 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Martin AnlaufEberhard Weihe
Jan 31, 2004·Biochemical and Biophysical Research Communications·Ian R SweetKenneth A Krohn
Mar 10, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuxin LuDaniel L Kaufman
Apr 20, 2004·Nuclear Medicine and Biology·A SchmitzA A Alavi
Jul 3, 2004·Endocrinology·Antonella MaffeiPaul E Harris
Nov 25, 2004·Diabetes·Gordon C Weir, Susan Bonner-Weir
Jun 2, 2005·Journal of Materials Science. Materials in Medicine·H ZimmermannU Zimmermann
Jun 14, 2005·Diabetes Research and Clinical Practice·Teemu KalliokoskiPirjo Nuutila
Aug 20, 2005·The Journal of Clinical Investigation·Stuart E TurveyDiane Mathis
Sep 1, 2005·The Journal of Biological Chemistry·Blanca RubíPierre Maechler
Nov 1, 2005·Nature Biotechnology·I Jolanda M de VriesCarl G Figdor
Nov 22, 2005·Transplantation Proceedings·Z BerkovaF Saudek
Dec 29, 2005·Nature Medicine·Natalia V EvgenovAnna Moore
May 20, 2006·The Journal of Clinical Investigation·Fabiola SouzaPaul E Harris
May 25, 2006·Cell Transplantation·Barjor GimiBrian B Roman
May 27, 2006·Chemical Society Reviews·Mark WoodsA Dean Sherry
Jul 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuxin LuDaniel L Kaufman
Sep 29, 2006·Journal of Medicinal Chemistry·Xavier MontetLee Josephson
Oct 19, 2006·Nuclear Medicine and Biology·Norman Ray SimpsonPaul Emerson Harris
Oct 27, 2006·Diabetes·Joo Ho TaiDavid J G White
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Martin GotthardtOtto Boerman
Apr 5, 2007·Nature Protocols·Zdravka MedarovaAnna Moore
Jul 12, 2007·Journal of Magnetic Resonance Imaging : JMRI·Tristan BarrettPeter L Choyke
Aug 1, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paul E HarrisAntonella Maffei

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Citations

May 24, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lu YangLiangyi Chen
Jul 18, 2012·Diabetologia·J Ahnfelt-RønneO D Madsen
Oct 18, 2012·Journal of Diabetes Investigation·Soroku Yagihashi
Nov 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Erik H J G AarntzenWim J G Oyen
Oct 9, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kirsi MikkolaNuutila Pirjo
Feb 21, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Oskar SkogOlle Korsgren
Aug 1, 2015·Diabetes, Obesity & Metabolism·D LaurentJ Hecksher-Sørensen
Oct 3, 2014·Endocrine Journal·Wataru NishimuraKazuki Yasuda
Jun 12, 2013·Journal of Internal Medicine·B Thorens
Apr 15, 2014·Trends in Endocrinology and Metabolism : TEM·Martin GotthardtMaarten Brom
Nov 29, 2014·Nature Reviews. Drug Discovery·Omid VeisehRobert Langer
Jun 24, 2015·Cell Transplantation·Rita NanoLorenzo Piemonti
Jun 9, 2016·Journal of Cell Science·Ge LiMingming Hao
Mar 15, 2018·Journal of Personalized Medicine·Rita Sofia Garcia RibeiroUwe Himmelreich
Aug 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stéphane DemineDecio L Eizirik
Nov 11, 2017·Scientific Reports·Alexander BalhuizenNick Devoogdt
Oct 7, 2020·International Journal of Molecular Sciences·Stephane DemineDecio L Eizirik
May 1, 2021·Biomolecules·Léa BerlandMohammad Rashidian
Jul 13, 2021·Frontiers in Endocrinology·Takaaki MurakamiNobuya Inagaki
Dec 11, 2017·ACS Biomaterials Science & Engineering·Sary SarkisCorinne A Hoesli
Feb 11, 2020·Journal of the American Chemical Society·Nam-Young KangYoung-Tae Chang
Oct 16, 2021·Molecular Pharmaceutics·Maria ErikssonEsteban N Gurzov
Aug 6, 2019·Advanced Drug Delivery Reviews·Weijun WeiWeibo Cai

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Methods Mentioned

BETA
phage-display
genetic modification

Software Mentioned

PARACEST
CEST

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