PMID: 9425583Jan 13, 1998Paper

Obstetric complications of antiphospholipid antibodies

Current Opinion in Obstetrics & Gynecology
R Rai, L Regan

Abstract

Pregnancies occurring in women with antiphospholipid antibodies are at significantly increased risk of miscarriage, prematurity, intrauterine growth retardation and preeclampsia. Insights into the pathological basis of these conditions suggest that antiphospholipid antibodies impair embryonic implantation and in later gestations cause thrombosis of the uteroplacental vasculature. This offers a rational basis for thromboprophylaxis during pregnancy.

Citations

Sep 13, 2003·Fertility and Sterility·Hans-Ulrich PauerBernd Hinney
Sep 7, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·O OguehA Benjamin
Jan 12, 2001·Obstetrics and Gynecology·M DreyfusJ L Pasquali
Feb 11, 2003·Obstetrics and Gynecology·Xiu Quan ZhangKenneth Ward
May 8, 2007·Journal of Reproductive Immunology·Debra S Goldman-Wohl, Simcha Yagel
Jan 13, 2009·Blood Reviews·Galit SarigBenjamin Brenner
Jul 23, 1999·Annals of the New York Academy of Sciences·M Costa, E Rossi

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.