Obstetric consequences of subfertility: a retrospective cohort study

BJOG : an International Journal of Obstetrics and Gynaecology
A L DoPieralaS Bhattacharya

Abstract

To compare the risk of adverse pregnancy outcomes in women with and without subfertility and to investigate whether fertility treatment contributes to the adverse outcomes. Register-based retrospective cohort study. Aberdeen, Scotland The exposed group included women with subfertility attending Aberdeen Fertility Clinic between 1989 and 2008 and delivering a singleton (n = 3188) or twin (n = 350) at Aberdeen Maternity Hospital between 1992 and 2009. The unexposed cohort included the remainder of women (singleton n = 52443, twin n = 1125) delivering at Aberdeen Maternity Hospital between 1992 and 2009. The Aberdeen Fertility Centre database and Aberdeen Maternity and Neonatal Databank were linked using Community Health Index numbers. Regression models were used to calculate risk ratios and 95% confidence intervals adjusting for potential confounders. Maternal outcomes including pre-eclampsia, antepartum haemorrhage, preterm birth, induction of labour; delivery outcomes including operative vaginal delivery, caesarean section; and offspring outcomes including low birthweight, stillbirth and neonatal death. Women with a history of subfertility who delivered a singleton were at a higher risk of pre-eclampsia [adjusted risk ratios (a...Continue Reading

References

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Citations

May 3, 2019·BMC Pregnancy and Childbirth·Amir Almasi-HashianiSaman Maroufizadeh
Dec 20, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reza Omani-SamaniPayam Amini
May 21, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Puyu YangZhangxin Wu
Jan 26, 2021·European Journal of Epidemiology·Maria C MagnusSiri E Håberg
Nov 23, 2020·Pregnancy Hypertension·Noora JaatinenEeva Ekholm

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