Obstetric outcomes after fresh versus frozen-thawed embryo transfers: A systematic review and meta-analysis

JBRA Assisted Reproduction
Matheus RoqueSelmo Geber

Abstract

To evaluate if there are differences in the risks of obstetric outcomes in IVF/ICSI singleton pregnancies when compared fresh to frozen-thawed embryo transfers (FET). This was a systematic review and meta-analysis evaluating the obstetric outcomes in singleton pregnancies after FET and fresh embryo transfer. The outcomes included in this study were pregnancy-induced hypertension (PIH), pre-eclampsia, placenta previa, and placenta accreta. The search yielded 654 papers, 6 of which met the inclusion criteria and reported on obstetric outcomes. When comparing pregnancies that arose from FET or fresh embryo transfer, there was an increase in the risk of obstetric complications in pregnancies resulting from FET when compared to those emerging from fresh embryo transfers in PIH (aOR 1.82; 95% CI 1.24-2.68), pre-eclampsia (aOR 1.32, 95% CI 1.07, 1.63), and placenta accreta (aOR 3.51, 95% CI 2.04-6.05). There were no significant differences in the risk between the FET and fresh embryo transfer groups when evaluating placenta previa (aOR 0.70; 95% CI 0.46-1.08). The obstetric outcomes observed in pregnancies arising from ART may differ among fresh and FET cycles. Thus, when evaluating to perform a fresh embryo transfer or a freeze-all c...Continue Reading

Citations

Jul 3, 2018·Panminerva Medica·Matheus RoqueSandro C Esteves
Jan 6, 2021·Archives of Gynecology and Obstetrics·Avital WertheimerYoel Shufaro
Nov 27, 2021·Experimental and Therapeutic Medicine·Andreea Mădălina BănicăSimona Vlădăreanu

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