PMID: 10784475Apr 28, 2000Paper

Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort

The American Journal of Psychiatry
I M RossoT L Gasperoni

Abstract

Although case-control investigations have shown an association between obstetric complications and schizophrenia, particularly among patients with early onsets, cohort studies have mostly failed to confirm this effect. The authors examined whether a history of fetal hypoxia and other obstetric complications elevated risk for early-onset schizophrenia in a 1955 Helsinki birth cohort. The subjects were 80 randomly selected patients with schizophrenia (36 with early and 44 with later onsets) representative of all available probands in the cohort, 61 of their nonschizophrenic siblings, and 56 demographically matched nonpsychiatric comparison subjects. Psychiatric diagnoses were obtained from structured clinical interviews, and obstetric data were taken from standardized, prospectively ascertained obstetric records. A score for hypoxia-associated obstetric complications was entered into logistic regression models, along with measures of prenatal infection and fetal growth retardation. Hypoxia-associated obstetric complications significantly increased the odds of early-onset schizophrenia but not of later-onset schizophrenia or unaffected sibling status, after prenatal infection and fetal growth retardation were taken into account. T...Continue Reading

Citations

Nov 25, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Amy ChuiPadma Murthi
Jan 5, 2011·European Archives of Psychiatry and Clinical Neuroscience·Angela FavaroPaolo Santonastaso
Dec 21, 2000·Current Psychiatry Reports·J Kelly, R M Murray
Apr 6, 2004·Brain Research. Brain Research Reviews·Patricia Boksa
Oct 26, 2013·Journal of Psychiatric Research·Magdalena Kotlicka-AntczakTomasz Pawełczyk
Oct 8, 2008·Development and Psychopathology·Katherine H KarlsgodtTyrone D Cannon
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
Nov 25, 2005·Schizophrenia Bulletin·Mary Catherine ClarkeMary Cannon
Jul 19, 2008·Schizophrenia Bulletin·Vijay A MittalTyrone D Cannon
Jun 10, 2005·The Australian and New Zealand Journal of Psychiatry·Yang YunPatrick D McGorry
Dec 18, 2007·Psychiatry and Clinical Neurosciences·Osamu NishizawaTsuyoshi Kondo
Jul 31, 2001·Pediatric Research·G Ceresoli-Borroni, R Schwarcz
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Han Sung HwangYoung Han Kim
Nov 1, 2001·Expert Review of Neurotherapeutics·J Boydell
Jul 6, 2007·Expert Review of Neurotherapeutics·Xiaoduo FanDavid C Henderson
Mar 6, 2016·Neuropharmacology·Francesca M Notarangelo, Ana Pocivavsek
Oct 28, 2009·Progress in Neurobiology·Urs Meyer, Joram Feldon
Aug 28, 2007·The Psychiatric Clinics of North America·Erick L MessiasWilliam W Eaton
Jul 26, 2008·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Franz Resch
Aug 1, 2009·Early Intervention in Psychiatry·Vijay A MittalTyrone D Cannon
Sep 6, 2003·Acta Psychiatrica Scandinavica·E W C ChowA S Bassett
Jun 13, 2006·Developmental Science·Michelle de HaanMortimer Mishkin
Dec 17, 2009·The American Journal of Pathology·Gayathri RajaramanBill Kalionis
Jan 12, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·M WalsheR M Murray
May 14, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Georges Boog
May 4, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Koichi OharaHaruo Shibuya
May 20, 2008·Biological Psychiatry·Tyrone D CannonUNKNOWN Collaborative Study Group on the Perinatal Origins of Severe Psychiatric Disorders
Jul 5, 2005·Biological Psychiatry·Anna E OrdoñezNitin Gogtay
Apr 9, 2016·Schizophrenia Bulletin·Emanuel SchwarzAndreas Meyer-Lindenberg
Feb 27, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T P H NguyenP Murthi
Nov 29, 2015·Schizophrenia Bulletin·Sinéad M O'NeillAli S Khashan
Dec 6, 2011·The American Journal of Pathology·Amy ChuiJoanne M Said

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