Obstetrical analgesia assessed by free fatty acid mobilisation.

Acta Anaesthesiologica Scandinavica
J M MaltauS Skrede

Abstract

Two groups of six parturients each have been compared. One group received centrally acting analgesics, sedatives and intermittent nitrous oxide and the other group was given epidural anaesthesia. The serum free fatty acid (FFA) concentrations of the parturients in the former group increased steadily during labour, attaining peak values between 1050 and 1750 mumol/l at delivery. In parturients belonging to the epidural group, the serum FFA concentrations remained level or even fell towards the time of delivery. It is suggested that the increase in serum FFA reflects a stress induced adrenergic lipolysis which may be used to assiss the various methods for obstetrical analgesia. It is concluded that epidural anaesthesia is superior to the conventional methods of pain relief. Analyses of blood sampled from the unbilical veins show that the concentrations of FFA in the blood of the newborns do not reflect the corresponding maternal values. Thus, epidural anaesthesia does not seem to deprive the fetus of FFA during labour since the factor limiting its transfer appears to be independent of the concentration gradient over the placental membrane.

References

Jan 1, 1975·Acta Obstetricia Et Gynecologica Scandinavica·J M Maltau, H T Andersen
Feb 1, 1956·The Journal of Clinical Investigation·V P DOLE
Feb 1, 1956·The Journal of Clinical Investigation·R S GORDON, A CHERKES
Jun 1, 1959·Experimental Neurology·C J BAILEY, L GUTH
Aug 1, 1962·The American Journal of Physiology·P BJORNTORP, R H FURMAN
Jul 1, 1964·Clinical Pharmacology and Therapeutics· VON EULERU
May 15, 1965·American Journal of Obstetrics and Gynecology·G H NELSON
Oct 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·B LEBOEUFG F CAHILL

❮ Previous
Next ❯

Citations

Sep 1, 1979·Canadian Anaesthetists' Society Journal·G M CooperJ Alaghband-Zadeh
May 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P Brownridge
Jan 1, 1975·Acta Anaesthesiologica Scandinavica·J M Maltau, H T Andersen
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·R JouppilaN Kärki
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·S Gullestad, N Sagen
Jan 13, 1979·British Medical Journal·J S Crawford
Feb 1, 1988·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S A WahabA A Saleh
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M R ClausenF Bendtsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.