Obstetrical prognosis of labour induction with mifepristone after 41 weeks of gestation

Gynécologie, obstétrique & fertilité
D GallotD Lémery

Abstract

To compare the mode of delivery in two groups of patients selected by their response after induction of labour with mifepristone. We studied retrospectively 89 cases of labour induction with viable children after 41 weeks of gestation. Bishop scores were less than 6. Patients were given 200 mg of mifepristone per day for 48 h. They were retrospectively divided into group 1 (spontaneous onset of labour or premature rupture of membranes before the third day) and group 2 (not in labour by that date). The mean Bishop score at inclusion was 3.1 +/- 1.3. Among the 51 patients (53.9%) in group 1, one required prostaglandins and we performed 10 cesarean sections. In group 2, the mean Bishop score at the 3rd day was 4.4 +/- 1.3 (P < 0.0001). Twenty-four patients required prostaglandins (P < 0.0001) and we performed 17 cesarean sections (P = 0.01). The number of cesarean sections increased with the dose of prostaglandins (P = 0.025). We observed no maternal or fetal complications. Mifepristone was successful in inducing labour spontaneously in over 50% of pregnancies after 41 weeks of gestation. In the other group, the probability of vaginal delivery was reduced especially when high doses of prostaglandins were required. After the use of...Continue Reading

References

Jun 1, 1990·British Journal of Obstetrics and Gynaecology·N C HillI Z Mackenzie
Aug 1, 1990·American Journal of Obstetrics and Gynecology·D CabrolA Treisser
Jun 1, 1994·British Journal of Obstetrics and Gynaecology·C LelaidierR Frydman
Jun 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B HaddadD Cabrol
Oct 30, 1998·Obstetrics and Gynecology·C L ElliottA A Calder
Oct 27, 1999·Acta Obstetricia Et Gynecologica Scandinavica·P M StenlundM Bygdeman
Sep 8, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B SelamT Ozcan
Oct 24, 2000·Obstetrics and Gynecology·L RandE R Norwitz
Jun 1, 2001·Obstetrics and Gynecology·J M AlexanderK J Leveno
Jul 14, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C F van HeterenJ G Nijhuis
Aug 8, 2001·Paediatric and Perinatal Epidemiology·T LiJ Smulian
Mar 27, 2002·Current Opinion in Obstetrics & Gynecology·Brian Hollis
Jun 12, 2003·Obstetrics and Gynecology·Luis Sanchez-RamosAndrew M Kaunitz
May 5, 2004·Gynécologie, obstétrique & fertilité·J-M Gonnet

❮ Previous
Next ❯

Citations

Aug 11, 2007·The Journal of Obstetrics and Gynaecology Research·Mohamed Furukan Mohamed Rameez, Indra Malik Rodrigo Goonewardene

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.