Obstructive colon cancers at endoscopy are associated with advanced tumor stage and poor patient outcome. A retrospective study on 398 patients.

European Journal of Gastroenterology & Hepatology
Fadi Abu BakerYael Kopelman

Abstract

The detection of obstructive colorectal cancer (CRC) masses during endoscopic examination hindering the passage of endoscope and precluding complete examination is not uncommon. The significance and implications of this finding on patients' prognosis and outcomes were not fully investigated and will be addressed in this study. In this retrospective cohort study, we reviewed endoscopy, surgery, pathology and oncology reports of patients diagnosed with CRC over a 10-year period (2007-2016). We compared surgical stages, histologic grades and overall survival between patients with subclinical obstructive tumors at endoscopy to those with nonobstructive tumors. We performed multivariate analysis to identify independent risk factors associated with advanced CRC stage at diagnosis. A total of 144 patients had obstructive colonic tumors while 254 had nonobstructive tumors and constituted the control group. Obstructive CRC group was significantly associated with advanced tumor stage at diagnosis (69 vs. 42%, OR = 3.018, 95% CI, 1.951-4.670; P < 0.01) and had prominently higher rates of moderate to poorly differentiated tumors (64.5 vs. 38.4%; P < 0.001) when compared to non-obstructive controls. Patients with obstructive tumors were sig...Continue Reading

References

Mar 15, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·K M HortonE K Fishman
Jan 4, 2006·Surgical Oncology Clinics of North America·James T McCormick, Sharon G Gregorcyk
Aug 19, 2007·World Journal of Gastroenterology : WJG·Min Sun Kim, Young Jin Park
Mar 7, 2008·Diseases of the Colon and Rectum·Hak-Mien QuahMartin R Weiser
Mar 26, 2008·American Journal of Surgery·Sebastiano BiondoRamon Salazar
Feb 26, 2009·The American Journal of Gastroenterology·Douglas K RexUNKNOWN American College of Gastroenterology
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Dec 14, 2011·Archives of Internal Medicine·Y Nancy YouJanice N Cormier
Jul 17, 2012·Digestive Diseases and Sciences·Raxitkumar JinjuvadiaSuthat Liangpunsakul
Aug 14, 2012·Gastroenterology·Anne F PeeryNicholas J Shaheen
Sep 10, 2013·World Journal of Emergency Surgery : WJES·Virote ChalieopanyarwongSurasak Sangkhathat
Nov 15, 2013·Lancet·Hermann BrennerChristian Peter Pox
Jan 1, 2014·World Journal of Gastroenterology : WJG·Hugh James Freeman
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 26, 2016·Oncotarget·Takaharu KatoToshiki Rikiyama
Feb 1, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Masayoshi YasuiUNKNOWN Clinical Study Group of Osaka University (CSGO), Colorectal Group
May 16, 2017·The Surgical Clinics of North America·Canaan BaerAmir Bastawrous
Aug 27, 2017·World Journal of Surgical Oncology·Tsung-Ming ChenGuan-Chyuan Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Terapevticheskiĭ arkhiv
A V Shul'gin, F F Vysokiĭ
Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
Neyda Milagros Torres ZavalaOthoniel Abelardo Burgos Chávez
© 2021 Meta ULC. All rights reserved