Obstructive sleep apnea and comorbidities: a dangerous liaison

Multidisciplinary Respiratory Medicine
Maria R BonsignoreOreste Marrone

Abstract

Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged recently, and new conditions significantly associated with OSA are increasingly reported. A high comorbidity burden worsens prognosis, but some data suggest that CPAP might be protective especially in patients with comorbidities. Aim of this narrative review is to provide an update on recent studies, with special attention to cardiovascular and cerebrovascular comorbidities, the metabolic syndrome and type 2 diabetes, asthma, COPD and cancer. Better phenotypic characterization of OSA patients, including comorbidities, will help to provide better individualized care. The unsatisfactory adherence to CPAP in patients without daytime sleepiness should prompt clinicians to examine the overall risk profile of each patient in order to identify subjects at high risk for worse prognosis and provide the optimal treatment not only for OSA, but also for comorbidities.

References

Aug 1, 1989·The American Review of Respiratory Disease·V BelliaG Bonsignore
Jan 1, 1995·American Journal of Respiratory and Critical Care Medicine·A ChaouatR Kessler
Jun 21, 2001·Respiration; International Review of Thoracic Diseases·L G LarssonUNKNOWN Obstructive Lung Disease in Northern Sweden Studies
Nov 12, 2003·Hypertension·Robert WolkVirend K Somers
Dec 16, 2005·Chest·Domenico Maurizio ToraldoNicolino Ambrosino
Jul 4, 2006·Sleep Medicine·Mihaela TeodorescuRonald D Chervin
Oct 20, 2006·The European Respiratory Journal·C LafondC Lemière
Feb 3, 2007·American Journal of Respiratory and Critical Care Medicine·Nao IiyoriChristopher P O'Donnell
Mar 29, 2008·Sleep & Breathing = Schlaf & Atmung·Hadil Alotair, Ahmed Bahammam
Sep 5, 2008·The Journal of Clinical Investigation·Simon SchenkJerrold M Olefsky
Mar 7, 2009·Journal of Applied Physiology·Mariam Louis, Naresh M Punjabi
May 2, 2009·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Mohammed AlharbiAhmed S Bahammam
Jun 30, 2009·The Journal of Allergy and Clinical Immunology·Joanne Y JulienR John Kimoff
Jul 4, 2009·The European Respiratory Journal·M-C L MachadoJ A Krishnan
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Jose M MarinBartolome R Celli
May 25, 2010·Chest·Mihaela TeodorescuNizar N Jarjour
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·Jean-Louis PépinJean-Philippe Baguet
May 12, 2011·PloS One·Sofia B AhmedPatrick J Hanly
Jul 26, 2011·The Journal of Allergy and Clinical Immunology·Anne E DixonCharles G Irvin
Sep 2, 2011·European Respiratory Review : an Official Journal of the European Respiratory Society·A AgustiS Rennard
Sep 17, 2011·The European Respiratory Journal·M R BonsignoreJ Eckel
Oct 14, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jamie Chung Mei LamMary Sau Man Ip
Nov 22, 2011·Sleep & Breathing = Schlaf & Atmung·Faith S LuysterSally E Wenzel
Jan 24, 2012·The European Respiratory Journal·Sheila SivamRonald R Grunstein
May 23, 2012·American Journal of Respiratory and Critical Care Medicine·F Javier NietoRamon Farré
Jun 23, 2012·American Journal of Respiratory and Critical Care Medicine·Abd A TahraniMartin J Stevens
Jun 28, 2012·Journal of Sleep Research·Maxime O BaudJean-Marie Petit
Jul 24, 2012·Sleep Medicine Reviews·Chong Weng OngGarun S Hamilton
Sep 26, 2012·BMC Pulmonary Medicine·Laurence Robichaud-HalléMartin Fortin
Sep 29, 2012·The European Respiratory Journal·Össur I EmilssonChrister Janson
Oct 31, 2012·European Journal of Clinical Investigation·Oreste MarroneGiuseppe Insalaco
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Francisco Campos-RodriguezUNKNOWN Spanish Sleep Network
Feb 12, 2013·The European Respiratory Journal·Gianfranco ParatiUNKNOWN EU COST Action B26 members
Mar 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mi-Yeong KimSae-Hoon Kim
May 28, 2013·Yonsei Medical Journal·Min Kwang ByunMoo Suk Park
Jun 5, 2013·Sleep & Breathing = Schlaf & Atmung·Sari Greenberg-DotanSteven M Scharf
Jun 19, 2013·Journal of the American College of Cardiology·Apoor S GamiVirend K Somers
Aug 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Michael L StanchinaAtul Malhotra
Oct 2, 2013·Sleep·Anne Sofie ChristensenNaja Hulvej Rod
Dec 7, 2013·Sleep Disorders·Mihaela TeodorescuMihai C Teodorescu
Jan 17, 2014·The Lancet. Respiratory Medicine·R Nisha Aurora, Naresh M Punjabi

❮ Previous
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Citations

Apr 16, 2020·American Journal of Respiratory and Critical Care Medicine·Eileen B LearyReena Mehra
Feb 29, 2020·Menopause : the Journal of the North American Menopause Society·Marta TorresIsaac Almendros
May 8, 2020·Metabolic Syndrome and Related Disorders·Kostas ArchontogeorgisPaschalis Steiropoulos
Aug 15, 2019·Journal of Medical Case Reports·Michael ProothiAvram R Gold
Sep 27, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Marie MarklundJohan Verbraecken
Aug 21, 2020·NPJ Primary Care Respiratory Medicine·Alan KaplanDavid M G Halpin
Oct 23, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Guoping YinJingying Ye
Mar 13, 2020·Frontiers in Medicine·Alison W Rebman, John N Aucott
Jul 18, 2019·Multidisciplinary Respiratory Medicine·Marta Marin-OtoJose M Marin
Jul 3, 2020·Therapeutic Advances in Endocrinology and Metabolism·Saleem AnsariNadim Haboubi
Oct 23, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Amrita PalPaul M Macey
Oct 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Jinxiang XiHaibo Dong
Nov 13, 2020·Sleep Medicine·Francesco ValentiniMaria Pia Villa
Dec 2, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Wen WangHaiyan Lu
Dec 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laetitia S GasparAlexandrina Ferreira Mendes
Jan 17, 2021·Sleep Medicine·Renata L RihaUNKNOWN ESADA collaborators
Nov 26, 2020·International Journal of Molecular Sciences·David GozalRamon Farré
Mar 6, 2021·Sleep Medicine· MohitPooran Chand
Mar 13, 2021·Sleep & Breathing = Schlaf & Atmung·Patrícia PaulettoGraziela De Luca Canto
Apr 7, 2021·Sleep & Breathing = Schlaf & Atmung·Sílvia Thamilis Barbosa Pessoa FerreiraAnna Myrna Jaguaribe de Lima
Apr 29, 2021·BMC Anesthesiology·Lisa SangkumCherdkiat Karnjanarachata
May 5, 2021·Sleep & Breathing = Schlaf & Atmung·Dries TestelmansB Buyse
May 14, 2021·Microvascular Research·Nevra Gullu Arslan, Gunseli Sefika Pancar
May 13, 2021·European Journal of Internal Medicine·Domenico ScrutinioMauro Carone
Jul 3, 2021·Clinics in Geriatric Medicine·Arpan Patel, Derek J Chong
Jun 26, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Lindsey J WanbergSusan Redline
Jun 26, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Yoshinari NakatsukaKazuo Chin
Jul 25, 2021·Journal of Clinical Medicine·Cindy ZolotoffNathalie Perek
Aug 25, 2020·Medicina clínica·Romina AbelleiraLuis Valdés
Jul 31, 2021·Sleep Medicine Clinics·Johan Verbraecken
Aug 17, 2021·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Chia-Ling LinWu-Chien Chien
Aug 16, 2021·Sleep Medicine·Sushanth Bhat, Sudhansu Chokroverty

❮ Previous
Next ❯

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