Obstructive sleep apnea and dyslipidemia: implications for atherosclerosis.

Current Opinion in Endocrinology, Diabetes, and Obesity
Luciano F DragerVsevolod Y Polotsky

Abstract

The aim of this review is to summarize current evidence about the impact of obstructive sleep apnea (OSA) and intermittent hypoxia on dyslipidemia and provide future perspectives in this area. Intermittent hypoxia, a hallmark of OSA, induces hyperlipidemia in lean mice. Hyperlipidemia of intermittent hypoxia occurs, at least in part, due to activation of the transcription factor sterol regulatory element-binding protein-1 (SREBP-1) and an important downstream enzyme of triglyceride and phospholipid biosynthesis, stearoyl-CoA desaturase-1. Furthermore, intermittent hypoxia may regulate SREBP-1 and stearoyl-CoA desaturase-1 via the transcription factor hypoxia-inducible factor 1. In contrast, key genes involved in cholesterol biosynthesis, SREBP-2 and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are unaffected by intermittent hypoxia. In humans, there is no definitive evidence regarding the effect of OSA on dyslipidemia. Several cross-sectional studies suggest that OSA is independently associated with increased levels of total cholesterol, low-density lipoprotein and triglycerides, whereas others report no such relationship. Some nonrandomized and randomized studies show that OSA treatment with continuous positive airway p...Continue Reading

References

Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
Jul 4, 2001·American Journal of Epidemiology·A B NewmanUNKNOWN Sleep Heart Health Study Research Group
Oct 11, 2003·American Journal of Respiratory and Critical Care Medicine·Mary S M IpWah-Kit Lam
May 4, 2004·European Heart Journal·Steven R CoughlinJohn P H Wilding
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Lorenzi-Filho
Jun 25, 2005·Atherosclerosis·Kathryn C B TanMary S M Ip
Jul 23, 2005·Journal of Applied Physiology·Jianguo LiVsevolod Y Polotsky
Aug 27, 2005·American Journal of Respiratory and Critical Care Medicine·Kenji MinoguchiMitsuru Adachi
Aug 27, 2005·Circulation Research·Jianguo LiVsevolod Y Polotsky
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
Oct 28, 2006·American Journal of Respiratory and Critical Care Medicine·Nigel McArdleGerald Watts
Nov 4, 2006·Journal of Applied Physiology·Jianguo LiVsevolod Y Polotsky
Jan 26, 2007·The European Respiratory Journal·S R CoughlinP M A Calverley
Mar 3, 2007·American Journal of Respiratory and Critical Care Medicine·Vladimir SavranskyVsevolod Y Polotsky
Jun 9, 2007·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Filho Lorenzi
Feb 16, 2008·American Journal of Respiratory and Critical Care Medicine·David GozalLeila Kheirandish-Gozal
Mar 7, 2008·The European Respiratory Journal·B LefebvreF Stanke-Labesque
Jun 3, 2008·Sleep Medicine Clinics·Jonathan Jun, Vsevolod Y Polotsky
Feb 10, 2009·Sleep Medicine·Frédéric RocheUNKNOWN PROOF Study Group
Jun 10, 2009·ILAR Journal·Jonathan Jun, Vsevolod Y Polotsky
Aug 19, 2009·PLoS Medicine·Naresh M PunjabiJonathan M Samet

❮ Previous
Next ❯

Citations

Dec 16, 2011·Sleep & Breathing = Schlaf & Atmung·Aibek E Mirrakhimov
Oct 14, 2011·Current Opinion in Cardiology·Ken Monahan, Susan Redline
Dec 20, 2012·American Journal of Physiology. Endocrinology and Metabolism·Jonathan C JunVsevolod Y Polotsky
May 25, 2012·American Journal of Physiology. Endocrinology and Metabolism·Jonathan C JunVsevolod Y Polotsky
Jan 3, 2012·Advances in Nutrition·Xueqing LiuJames M Ntambi
Apr 17, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Faith S LuysterPatrick J Strollo
Aug 21, 2012·Sleep & Breathing = Schlaf & Atmung·Ajibola Monsur AdedayoGirardin Jean-Louis
Dec 2, 2014·Obesity Research & Clinical Practice·Abu ShamsuzzamanRaouf S Amin
Oct 14, 2014·The American Journal of Cardiology·Faith S LuysterPatrick J Strollo
Feb 7, 2013·Journal of Lipid Research·Qiaoling YaoVsevolod Y Polotsky
Dec 30, 2015·Current Atherosclerosis Reports·Fré BautersJulio A Chirinos
Feb 26, 2013·International Journal of Pediatric Otorhinolaryngology·Jing ZongXuan Chen
May 24, 2013·Chest·Wojciech TrzepizurUNKNOWN Institut de Recherche en Santé Respiratoire des Pays de la Loire (IRSR) Sleep Cohort Group
Jan 24, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Gabriel Sampol, Albert Lecube
Sep 29, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·E Van Cauter
May 7, 2013·Journal of Vascular Surgery·Chung S LimAlun H Davies
Jun 4, 2015·The Canadian Journal of Cardiology·Mohammad BadranNajib Ayas
Jun 19, 2013·Journal of the American College of Cardiology·Luciano F DragerGeraldo Lorenzi-Filho
Jun 22, 2014·General Hospital Psychiatry·Chieh-Sen ChuangChia-Hung Kao
Dec 17, 2014·Reviews in Endocrine & Metabolic Disorders·Dileep UnnikrishnanVsevolod Polotsky
Oct 19, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wojciech TrzepizurUNKNOWN Institut de Recherche en Santé Respiratoire des Pays de la Loire Sleep Cohort Group
Jul 8, 2016·Sleep & Breathing = Schlaf & Atmung·Ana Kelley L MedeirosRodrigo P Pedrosa
Sep 14, 2016·Brain, Behavior, and Immunity·Camila HirotsuMonica L Andersen
Aug 5, 2011·Chest·Luciano F DragerGeraldo Lorenzi-Filho
Mar 22, 2013·Angiology·Manfredi RizzoRuzena Tkacova
Oct 5, 2014·Chronic Respiratory Disease·Ian W Seetho, John P H Wilding
Oct 8, 2013·Asia-Pacific Journal of Public Health·Khanrin P VashumAbul Hasnat Milton
Nov 18, 2017·Metabolic Syndrome and Related Disorders·Luciana Oliveira E SilvaSonia M Togeiro
Aug 23, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Canan GündüzUNKNOWN European Sleep Apnea Database Collaborators
Jun 9, 2018·Circulation Research·John S Floras
Mar 1, 2018·PloS One·Max Jonathan StumpfIzabela Tuleta
Jul 2, 2019·Journal of Internal Medicine·C GunduzUNKNOWN European Sleep Apnoea Database collaborators
Dec 17, 2019·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Oleg Y ChernyshevAnil Nanda
Jan 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A-Ping SunXiao-Lu Liu
Jun 9, 2017·The Journal of Clinical Endocrinology and Metabolism·Swati ChopraJonathan C Jun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.