Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.

Anesthesiology
Benjamin J FlinkMadan M Kwatra

Abstract

Postoperative delirium, a common complication in the elderly, can occur following any type of surgery and is associated with increased morbidity and mortality; it may also be associated with subsequent cognitive problems. Effective therapy for postoperative delirium remains elusive because the causative factors of delirium are likely multiple and varied. Patients 65 yr or older undergoing elective knee arthroplasty were prospectively evaluated for postoperative Diagnostic and Statistical Manual of Mental Disorders-IV delirium. Exclusion criteria included dementia, mini-mental state exam score less than 24, delirium, clinically significant central nervous system/neurologic disorder, current alcoholism, or any serious psychiatric disorder. Delirium was assessed on postoperative days 2 and 3 using standardized scales. Patients' preexisting medical conditions were obtained from medical charts. The occurrence of obstructive sleep apnea was confirmed by contacting patients to check their polysomnography records. Data were analyzed using Pearson chi-square or Wilcoxon rank sum tests and multiple logistic regressions adjusted for effects of covariates. Of 106 enrolled patients, 27 (25%) developed postoperative delirium. Of the 15 patie...Continue Reading

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References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 1, 1992·Journal of the American Geriatrics Society·D G BuchsbaumS H Schnoll
Dec 15, 1990·Annals of Internal Medicine·S K InouyeR I Horwitz
Oct 1, 1994·Annals of Neurology·K A Hossmann
Mar 1, 1994·British Journal of Anaesthesia·L P Aakerlund, J Rosenberg
Jan 12, 1994·JAMA : the Journal of the American Medical Association·E R MarcantonioR Poss
Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
May 12, 1993·JAMA : the Journal of the American Medical Association·R M CrumM F Folstein
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·P EntzianP Zabel
May 1, 1996·The American Journal of Emergency Medicine·J F Whitney, D E Gannon
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A N VgontzasG P Chrousos
Apr 16, 1998·Anesthesia and Analgesia·E P LynchE R Marcantonio
May 16, 1998·General Hospital Psychiatry·J W Lee
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·X MuñozG Sampol
Nov 27, 1998·The American Journal of Medicine·E R MarcantonioT H Lee
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·A N VgontzasG P Chrousos
Feb 15, 2001·Archives of Internal Medicine·C A JonesM E Suarez-Almazor
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·E O BixlerA Kales
Jul 13, 2001·The Journal of Neuropsychiatry and Clinical Neurosciences·P T TrzepaczN Jimerson
Sep 22, 2001·The Medical Clinics of North America·N Winawer
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C Dean KurthJohn McCann
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Terry YoungDaniel J Gottlieb
Nov 14, 2002·Biochemical Pharmacology·Yiqun Hui, Colin D Funk
Jun 13, 2003·Clinics in Chest Medicine·Robert Wolk, Virend K Somers
Jun 24, 2003·Best Practice & Research. Clinical Anaesthesiology·Alex Y Bekker, Edwin J Weeks
Feb 7, 2004·The Annals of Otology, Rhinology, and Laryngology·Soo-Geun WangKyong-Myong Chon
May 1, 2004·The Journal of Bone and Joint Surgery. American Volume·Olivier EthgenJean-Yves Reginster
Sep 17, 2004·Acta Orthopaedica Scandinavica·Martin BitschHenrik Kehlet
Nov 25, 2004·Anesthesia and Analgesia·Akira KudohTomoko Takazawa
Apr 26, 2005·Journal of the American College of Surgeons·Luis F Amador, James S Goodwin
Jun 18, 2005·International Journal of Geriatric Psychiatry·A M ContínF Ramos
Nov 29, 2005·Journal of Cardiac Surgery·Sanjeev SockalingamShree Bhalerao
Dec 31, 2005·Psychosomatics·Jeff S SeamanThomas M Brown
Oct 14, 2006·Journal of the American Geriatrics Society·Monidipa Dasgupta, Andrea C Dumbrell
Jan 5, 2007·International Journal of Geriatric Psychiatry·Dimitrios AdamisAlastair J D Macdonald
Feb 28, 2007·Anesthesiology·Jeffrey H SilversteinSuzan Uysal
Apr 21, 2007·BMJ : British Medical Journal·John Young, Sharon K Inouye
Jul 13, 2007·Chest·Susheel P PatilPhilip L Smith
Mar 4, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James L RudolphEdward R Marcantonio
Apr 24, 2008·Anesthesiology·Frances ChungColin M Shapiro
Sep 17, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rui GaoQiang Fu
Dec 25, 2008·Annals of Surgery·Thomas N RobinsonMarc Moss

❮ Previous
Next ❯

Citations

Dec 22, 2012·British Journal of Anaesthesia·M SinghF Chung
Sep 20, 2012·Current Opinion in Pulmonary Medicine·Dennis Auckley, Norman Bolden
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Amy S GuralnickBabak Mokhlesi
Apr 16, 2013·Sleep & Breathing = Schlaf & Atmung·Aibek E MirrakhimovMadan M Kwatra
Mar 19, 2014·European Journal of Internal Medicine·Michele TerzaghiRaffaele Manni
Oct 8, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Emily YoungblomJacqueline Leung
Jul 20, 2014·Clinics in Geriatric Medicine·Nalaka S Gooneratne, Michael V Vitiello
Oct 9, 2012·Best Practice & Research. Clinical Anaesthesiology·Lene KrenkHenrik Kehlet
Sep 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Jens RoggenbachStefan Hofer
Oct 24, 2015·Clinical Therapeutics·Matthew K WhalinPaul S García
Mar 27, 2015·The Journal of the American Academy of Orthopaedic Surgeons·M Melanie LyonsIndira Gurubhagavatula
Dec 30, 2014·Pain Management·Ottokar StundnerStavros G Memtsoudis
Feb 11, 2015·Current Neurology and Neuroscience Reports·Raffaele Manni, Michele Terzaghi
Sep 3, 2014·Nature Reviews. Clinical Oncology·Peter G Lawlor, Shirley H Bush
Oct 19, 2016·Anesthesia and Analgesia·Susana VacasMervyn Maze
Apr 22, 2017·Anesthesia and Analgesia·Enoch W K LamJean Wong
May 5, 2017·Journal of the American Geriatrics Society·Andrew M NamenEdward F Haponik
Nov 16, 2017·British Medical Bulletin·L H LangM Maze
Jan 28, 2018·Journal of General Internal Medicine·Jennifer WattSharon E Straus
Sep 18, 2018·Critical Care Medicine·Ayòtúndé B FadayomiOluwaseun Akeju
Jan 5, 2018·European Journal of Anaesthesiology·Martin Roesslein, Frances Chung
Mar 24, 2016·F1000Research·Sebastian ZarembaMatthias Eikermann
May 22, 2019·The European Respiratory Journal·Maria TafelmeierMichael Arzt
Apr 4, 2015·Journal of the American Geriatrics Society·UNKNOWN AGS/NIA Delirium Conference Writing Group, Planning Committee and Faculty
Oct 10, 2019·JAMA Surgery·Nirvik PalJohn Butterworth
Nov 22, 2012·Anesthesiology·Lene Krenk, Henrik Kehlet
Oct 17, 2014·Expert Review of Clinical Pharmacology·Dan M McEntireCharles F Youngblood
Apr 3, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Hongbai WangFuxia Yan
Aug 25, 2020·Current Sleep Medicine Reports·Sadaf FarasatBiren B Kamdar
Nov 10, 2017·Current Opinion in Anaesthesiology·Xian Su, Dong-Xin Wang

❮ Previous
Next ❯

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