Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes.

Sleep
Omonigho M BubuAlzheimer’s Disease Neuroimaging Initiative

Abstract

To determine the effect of self-reported clinical diagnosis of obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers (Aβ42, T-tau, and P-tau) in cognitively normal (NL), mild cognitive impairment (MCI), and Alzheimer's disease (AD) elderly. Longitudinal study with mean follow-up time of 2.52 ± 0.51 years. Data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Participants included 516 NL, 798 MCI, and 325 AD elderly. Main outcomes were annual rate of change in brain amyloid burden (i.e. longitudinal increases in florbetapir PET uptake or decreases in CSF Aβ42 levels); and tau protein aggregation (i.e. longitudinal increases in CSF total tau [T-tau] and phosphorylated tau [P-tau]). Adjusted multilevel mixed effects linear regression models with randomly varying intercepts and slopes was used to test whether the rate of biomarker change differed between participants with and without OSA. In NL and MCI groups, OSA+ subjects experienced faster annual increase in florbetapir uptake (B = .06, 95% CI = .02, .11 and B = .08, 95% CI = .05, .12, respectively) and decrease in CSF Aβ42 levels (B = -2.71, 95% CI = -3.11, -2.35 and B = -2.62, 95% CI = -3.23, -2.03, res...Continue Reading

References

Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·J J HosseletD M Rapoport
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·J HosseletD M Rapoport
Jan 16, 2002·American Journal of Epidemiology·Miguel A HernánAllen A Mitchell
May 21, 2003·Archives of Neurology·Robert C GreenLindsay Farrer
Dec 21, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·L MosconiA Pupi
Feb 1, 2005·Annals of the New York Academy of Sciences·Natalia N NalivaevaaAnthony J Turner
Dec 21, 2005·Neuron·John R CirritoDavid M Holtzman
Nov 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiulian SunWeihong Song
Sep 25, 2007·Neurobiology of Aging·Miroslaw BrysMony J de Leon
Mar 7, 2008·Neuro-degenerative Diseases·Daniela Berg
May 17, 2008·Journal of the American Geriatrics Society·Mark L UnruhAnne B Newman
Mar 11, 2009·Archives of Neurology·Annette L FitzpatrickJosé A Luchsinger
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 3, 2009·Brain : a Journal of Neurology·Clifford R JackUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 12, 2010·Brain : a Journal of Neurology·Clifford R JackUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 13, 2011·Neuron·Yuval NirGiulio Tononi
May 3, 2011·Nature Neuroscience·Adam W BeroDavid M Holtzman
Oct 19, 2011·Advances in Cardiology·Alain Lurie
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Keith A JohnsonWilliam E Klunk
Nov 21, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susan M LandauUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 29, 2013·Annals of Neurology·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 19, 2013·Science·Lulu XieMaiken Nedergaard
Jun 3, 2014·JAMA Neurology·Michael C DonohueUNKNOWN Alzheimer’s Disease Cooperative Study
Jan 27, 2015·SAGE Open Medicine·Adam P SpiraMark N Wu
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
Apr 17, 2015·Neurology·Ricardo S OsorioUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 19, 2015·The Lancet. Respiratory Medicine·Ivana RosenzweigMary J Morrell
Dec 23, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vesa KiviniemiMaiken Nedergaard
Feb 13, 2016·The Lancet. Respiratory Medicine·Raphael HeinzerJosé Haba-Rubio
Nov 5, 2016·Sleep Medicine·Mako NagayoshiPamela L Lutsey
Dec 3, 2016·Journal of the International Neuropsychological Society : JINS·Emily C EdmondsUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 1, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steffi Dreha-KulaczewskiJens Frahm
May 28, 2017·Journal of Alzheimer's Disease : JAD·Chang-Ho YunRobert J Thomas
Aug 25, 2017·Neurology·Matthew P PaseSudha Seshadri
Sep 14, 2017·Brain : a Journal of Neurology·Yo-El S JuDavid M Holtzman
Nov 11, 2017·American Journal of Respiratory and Critical Care Medicine·Ram A SharmaRicardo S Osorio
Dec 11, 2017·Neuroscience and Biobehavioral Reviews·D PolsekI Rosenzweig

❮ Previous
Next ❯

Citations

Nov 2, 2019·Brain : a Journal of Neurology·Grant L IversonRudolph J Castellani
Apr 3, 2020·Human Brain Mapping·Bahram MohajerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 6, 2020·Sleep·Aditya AmbatiShahrad Taheri
Dec 4, 2019·Aging·Ling-Zhi MaAlzheimer's Disease Neuroimaging Initiative
May 31, 2019·Current Neurology and Neuroscience Reports·Gustavo C RománAparajitha K Verma
Nov 15, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Stephanie A Ward, Matthew P Pase
Jan 31, 2020·Frontiers in Aging Neuroscience·Jadwiga Attier-ZmudkaOlivier Balédent
Oct 2, 2019·Frontiers in Neurology·Audrey GabelleYves Dauvilliers
Jul 30, 2019·Frontiers in Cardiovascular Medicine·Meghna P MansukhaniVirend K Somers
Oct 20, 2020·Frontiers in Neuroscience·Bryce A Mander
Jan 6, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Anna E MullinsAndrew W Varga
Oct 7, 2020·Sleep Medicine Reviews·Claudio LiguoriBiancamaria Guarnieri
Nov 19, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kenneth RockwoodLindsay M K Wallace
Oct 23, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Omonigho M BubuUNKNOWN and Alzheimer's Disease Neuroimaging Initiative
Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Salla Ylä-HerttualaEsa Mervaala
Jan 26, 2021·Frontiers in Aging Neuroscience·Chih-Yun KuoTomas Nikolai
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Luigi Ferini-StrambiMaria Salsone
Feb 16, 2021·Current Neurology and Neuroscience Reports·Andrée-Ann BarilNadia Gosselin
Mar 2, 2021·Neural Regeneration Research·Huang KuangShu-Long Yang
Apr 6, 2021·Aging and Disease·Yayong Li, Yina Wang
Nov 5, 2020·Annals of the American Thoracic Society·Andrew E BeaudinPatrick J Hanly
May 3, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yajing LiuHaiqun Xie
May 13, 2021·Neuroscience Letters·Tengwei PanUNKNOWN on the behalf of Alzheimer’s Disease Neuroimaging Initiative
Jul 21, 2021·Translational Psychiatry·Katarina IlicSvjetlana Kalanj-Bognar
Jul 4, 2021·Practical Neurology·Jeremy C S JohnsonJason D Warren
Aug 31, 2021·JAMA Neurology·Joseph R WinerElizabeth C Mormino
Sep 11, 2021·Chinese Medical Journal·Willa D BrenowitzYue Leng
Sep 6, 2020·Current Biology : CB·Joseph R WinerMatthew P Walker

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.