Obstructive Sleep Apnea in Children with Down Syndrome: Demographic, Clinical, and Polysomnographic Features

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Bahir H ChamseddinRon B Mitchell

Abstract

To evaluate demographic, clinical, and polysomnographic features of children with Down syndrome suspected of having obstructive sleep apnea. To identify factors that predict severe obstructive sleep apnea among children with Down syndrome. Case series with chart review. Children's Medical Center Dallas / University of Texas Southwestern Medical Center. Demographic, clinical, and polysomnographic data were collected for children with Down syndrome aged 2 to 18 years. Simple and multivariable regression models were used to study predictors of severe obstructive sleep apnea (apnea-hypopnea index ≥10). P≤ .05 was considered significant. A total of 106 children with Down syndrome were included, with 89 (84%) <12 years old, 56 (53%) male, 72 (68%) Hispanic, 15 (14%) African American, and 14 (13%) Caucasian. Ninety percent of children had ≥1 medical comorbidities; 95 (90%) patients had obstructive sleep apnea; and 46 (44%) had severe obstructive sleep apnea. The mean SaO2 nadir was lower among obese than nonobese children (80% vs 85%, P = .02). Obese versus nonobese patients had a higher prevalence of severe obstructive sleep apnea (56% vs 35%, P = .03). Severe OSA was associated with heavier weight (odds ratio = 1.0, 95% CI: 1.0-1.1,...Continue Reading

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Citations

Jul 30, 2019·Journal of Intellectual Disability Research : JIDR·E K ChoiY J Lee
Aug 5, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Daniel C O'BrienBrian Kellermeyer
Jan 7, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Althea Robinson Shelton, Beth Malow
Mar 18, 2021·Pediatric Pulmonology·Lauren MacDonaghDes W Cox
Apr 17, 2021·The Laryngoscope·Rachel ManuelRomaine F Johnson
Sep 26, 2021·European Journal of Pediatrics·Mina HizalUgur Ozcelik
Nov 17, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Courtney JohnsonRon B Mitchell

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