Obstructive sleep apnea in patients with abdominal aortic aneurysms: highly prevalent and associated with aneurysm expansion

American Journal of Respiratory and Critical Care Medicine
Rebecca H MasonMalcolm Kohler

Abstract

Abdominal aortic aneurysms (AAA) are associated with life-threatening complications. The likelihood that an AAA will rupture is influenced by the aneurysm diameter and its expansion rate; reasons for rapid expansion are largely unknown. To determine the prevalence of obstructive sleep apnea (OSA) in patients with AAA, and investigate a possible association between OSA and rate of AAA expansion. A total of 127 patients (11 females), included in an AAA surveillance program, agreed to participate and underwent a sleep study. Annual AAA expansion was determined retrospectively from available ultrasound measurements. OSA was characterized using both oxygen desaturation index (ODI) and apnea-hypopnea index (AHI). Univariate and multivariate analysis was performed to assess the effect of OSA severity on AAA expansion. Mean age was 67.9 (SD, 6) years. Median interval between the first and last AAA measurements was 18 (range, 2-113) months. An ODI or AHI of greater than 10 was found in 40.5% and 41.5% of the patients, respectively. Patients with an ODI greater than 30 (n = 12) had a significantly faster median yearly AAA expansion rate (2.9; quartiles 2/5.7 mm/y) than patients with an ODI 0-5 (n = 47; 1.2; quartiles 0/3.1 mm/y) or 6-15 ...Continue Reading

References

Dec 1, 1991·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·E K YucelA C Waltman
Apr 1, 1989·AJR. American Journal of Roentgenology·L L LaRoyB Silver
Apr 1, 1988·Journal of Applied Physiology·J PetersJ L Robotham
Jun 1, 1984·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·M PäivänsaloA Leinonen
Oct 1, 1995·The Journal of Clinical Investigation·V K SomersF M Abboud
Aug 1, 1995·Journal of Applied Physiology·U LeuenbergerL Sinoway
Oct 1, 1994·Journal of Applied Physiology·E GarpestadJ W Weiss
Apr 22, 1993·The New England Journal of Medicine·C B Ernst
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·N V WaradekarU A Leuenberger
Apr 24, 1999·Annals of Internal Medicine·J A SaloP S Mattila
Apr 23, 2002·Archives of Internal Medicine·Terry YoungUNKNOWN Sleep Heart Health Study Research Group
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Terry YoungDaniel J Gottlieb
May 21, 2003·Journal of Vascular Surgery·David C BrewsterUNKNOWN Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery
Aug 9, 2003·American Journal of Respiratory and Critical Care Medicine·Gabriel SampolArturo Evangelista
Jun 24, 2004·Circulation·Anthony R BradyUNKNOWN UK Small Aneurysm Trial Participants
Jul 14, 2007·Antioxidants & Redox Signaling·Nanduri R PrabhakarGregg L Semenza
Jul 26, 2008·The European Respiratory Journal·M KohlerR J O Davies
Aug 30, 2008·Journal of the American College of Cardiology·Naoki SerizawaNobuhisa Hagiwara
Dec 5, 2008·Sleep & Breathing = Schlaf & Atmung·Hui ChenFernanda R Almeida

❮ Previous
Next ❯

Citations

Mar 29, 2011·Heart and Vessels·Hirokazu SaruharaAkira Yamashina
Dec 20, 2011·Journal of Hypertension·Jean-Philippe BaguetJean-Michel Mallion
Jun 19, 2012·American Journal of Respiratory and Critical Care Medicine·Thomas B RiceMary J Morrell
Aug 12, 2014·Annals of Vascular Surgery·Xuemin ZhangWei Guo
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Hans-Joachim EiseleRichard Schulz
Sep 11, 2014·Sleep & Breathing = Schlaf & Atmung·Vittorio E BianchiRonald L Dalman
Apr 30, 2016·American Journal of Respiratory and Critical Care Medicine·Susmita ChowdhuriUNKNOWN ATS Ad Hoc Committee on Mild Obstructive Sleep Apnea
Oct 26, 2016·La Presse médicale·Jean-Philippe Baguet
Mar 12, 2011·Chest·Anne-Christin StöwhasMalcolm Kohler
Mar 6, 2019·Journal of Neurology·Sebastian ZarembaErdem Güresir
Jun 27, 2015·The European Respiratory Journal·Thomas GaislMalcolm Kohler
Dec 17, 2019·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Oleg Y ChernyshevAnil Nanda
Nov 9, 2012·Expert Review of Respiratory Medicine·Vannan Kandi Vijayan
Oct 1, 2019·Journal of Atherosclerosis and Thrombosis·Yasuhiro TomitaKoji Narui
Jun 15, 2013·Journal of Applied Physiology·Christian F ClarenbachMalcolm Kohler
Apr 4, 2021·International Journal of Environmental Research and Public Health·Giuseppina LaganàCalogera Pisano
Nov 21, 2020·The European Respiratory Journal·Thomas GaislMalcolm Kohler
May 8, 2021·The European Respiratory Journal·Luciano F Drager, Miguel A Martinez-Garcia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.