Obstructive sleep apnea is an important predictor of hepatic fibrosis in patients with nonalcoholic fatty liver disease in a tertiary care center

Hepatology International
Swastik AgrawalYogesh Chawla

Abstract

The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. OSA was diagnosed by polysomnography, done in patients having symptoms of OSA, in patients with NAFLD attending the liver clinic. Polysomnography-proven patients with OSA attending the chest clinic were evaluated for NAFLD by ultrasonography. Anthropometry, liver function tests, metabolic syndrome evaluation and transient elastography were performed in all patients. Three (3%; 95% CI 1.03-8.45%) out of 100 patients with NAFLD (mean age 41 ± 11 years) had symptomatic OSA. Of 23 patients with OSA (mean age 46 ± 12 years,), 3 (13%) had mild, 5 (22%) moderate and 15 (65%) severe OSA. Twenty-one (91.3%; 95% CI 73.2-97.6%) patients with OSA had NAFLD, while raised hepatic transaminase levels were seen in seven (30.4%; 95% CI 15.6-50.9%). Body mass index (OR 1.21, 95% CI 1.02-1.44) and male gender (OR 4.79, 95% CI 1.12-20.48) were significant independent predictors of OSA in NAFLD. The apnea-hypopnea index (OR 1.084, 95% CI 1.002-1.17...Continue Reading

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Apr 12, 2016·Clinics in Liver Disease·Kristina R Chacko, John Reinus
Jun 22, 2016·Metabolism: Clinical and Experimental·Judith Aron-WisnewskyJean-Louis Pépin
Jun 9, 2018·The European Respiratory Journal·Wojciech TrzepizurUNKNOWN on the behalf of the METABOL group
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Feb 2, 2017·World Journal of Hepatology·Shira Zelber-SagiSigal Fishman
Jun 12, 2020·World Journal of Gastroenterology : WJG·Ilaria UmbroMaria Del Ben

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