Obstructive Sleep Apnea Is Associated With Altered Glycemic Patterns in Pregnant Women With Obesity.

The Journal of Clinical Endocrinology and Metabolism
Sarah S FarabiTeri L Hernandez

Abstract

Often unrecognized, obstructive sleep apnea (OSA) worsens over pregnancy and is associated with poorer perinatal outcomes. The association between OSA in late pregnancy and metabolic biomarkers remains poorly understood. We tested the hypothesis that OSA in pregnant women with obesity is positively correlated with 24-hour patterns of glycemia and IR despite controlling for diet. Pregnant women (32 to 34 weeks' gestation; body mass index, 30 to 40 kg/m2) wore a continuous glucose monitor for 3 days. OSA was measured in-home by WatchPAT 200™ [apnea hypopnea index (AHI), oxygen desaturation index (ODI; number per hour)]. Fasting blood was collected followed by a 2-hour, 75-g, oral glucose tolerance test to measure IR. Association between AHI and 24-hour glucose area under the curve (AUC) was the powered outcome. Of 18 women (29.4 ± 1.4 years of age [mean ± SEM]), 12 (67%) had an AHI ≥5 (mild OSA). AHI and ODI were correlated with 24-hour glucose AUC (r = 0.50 to 0.54; P ≤ 0.03) and mean 24-hour glucose (r = 0.55 to 0.59; P ≤ 0.02). AHI and ODI were correlated with estimated hepatic IR (r = 0.59 to 0.74; P < 0.01), fasting free fatty acids (fFFAs; r = 0.53 to 0.56; P < 0.05), and waking cortisol (r = 0.49 to 0.64; P < 0.05). Mild O...Continue Reading

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Citations

May 20, 2020·Journal of Developmental Origins of Health and Disease·Sarah S FarabiTeri L Hernandez
May 16, 2019·JAMA : the Journal of the American Medical Association·Anastasia-Stefania AlexopoulosAnne L Peters
Dec 18, 2020·The Journal of Clinical Endocrinology and Metabolism·Elizabeth O Buschur, Sarit Polsky
Feb 2, 2021·Endocrinology and Metabolism Clinics of North America·Amy M Valent, Linda A Barbour
Sep 2, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rachel L RodelBridget E Young

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