Obstructive sleep apnea is independently associated with arterial stiffness in ischemic stroke patients

Journal of Neurology
Chung-Yao ChenChung-Chieh Yu

Abstract

Obstructive sleep apnea (OSA) is a predictor of all-cause mortality and recurrent vascular events following stroke. However, few studies have investigated the pathophysiology of OSA in ischemic stroke patients. Whether OSA independently increases arterial stiffness in ischemic stroke patients is determined by measuring the carotid-femoral pulse wave velocity (PWV) and via the central augmentation index (AIx). This cross-sectional study consecutively recruited 127 subacute ischemic stroke patients who were admitted to a teaching hospital for inpatient rehabilitation (median age, 61.3 years; IQR 53.6-72.7 years). Vascular measurements were performed following polysomnography. Multivariate linear regression analysis was performed to determine the relationship between arterial stiffness and OSA. Patients with severe OSA were significantly older, had significantly higher PWV and mean blood pressure, and a significantly higher risk of hypertension than those with non-severe OSA. The significant bivariate correlation between AIx@75 and the desaturation index (DI) (Spearman's ρ = 0.182, P = 0.040) became insignificant by multivariate regression analysis. The PWV was significantly correlated with the apnea-hypopnea index (AHI) (Pearson'...Continue Reading

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Citations

Nov 15, 2016·Oxidative Medicine and Cellular Longevity·Mohammad BadranIsmail Laher
Mar 24, 2018·Journal of Hypertension·Paola MattalianoGianfranco Parati
Dec 19, 2017·Sleep & Breathing = Schlaf & Atmung·Zesheng WuZhidong Guo
Feb 20, 2019·International Journal of Molecular Sciences·Manabu Kadoya, Hidenori Koyama
Dec 19, 2019·Current Sleep Medicine Reports·H Lee LauAlberto R Ramos
May 4, 2017·Neurological Research·Zizhen XieFengchun Yu
Mar 11, 2021·Nature and Science of Sleep·Chung-Yao Chen, Chia-Ling Chen

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