Obstructive sleep apnea is independently associated with arterial stiffness in ischemic stroke patients
Abstract
Obstructive sleep apnea (OSA) is a predictor of all-cause mortality and recurrent vascular events following stroke. However, few studies have investigated the pathophysiology of OSA in ischemic stroke patients. Whether OSA independently increases arterial stiffness in ischemic stroke patients is determined by measuring the carotid-femoral pulse wave velocity (PWV) and via the central augmentation index (AIx). This cross-sectional study consecutively recruited 127 subacute ischemic stroke patients who were admitted to a teaching hospital for inpatient rehabilitation (median age, 61.3 years; IQR 53.6-72.7 years). Vascular measurements were performed following polysomnography. Multivariate linear regression analysis was performed to determine the relationship between arterial stiffness and OSA. Patients with severe OSA were significantly older, had significantly higher PWV and mean blood pressure, and a significantly higher risk of hypertension than those with non-severe OSA. The significant bivariate correlation between AIx@75 and the desaturation index (DI) (Spearman's ρ = 0.182, P = 0.040) became insignificant by multivariate regression analysis. The PWV was significantly correlated with the apnea-hypopnea index (AHI) (Pearson'...Continue Reading
References
Brachial-ankle pulse wave velocity is a strong predictor for mortality in patients with acute stroke
Citations
Recognizable Clinical Subtypes of Obstructive Sleep Apnea After Ischemic Stroke: A Cluster Analysis.
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