PMID: 6404205Apr 1, 1983Paper

Occlusion pressure and breathing pattern in patients with interstitial lung disease

The American Review of Respiratory Disease
A F DiMarcoB Gothe

Abstract

The ventilatory and occlusion pressure (P100) responses to hypercapnia, maximal inspiratory airway and transdiaphragmatic pressures, and the separate volume contributions of the rib cage and abdomen to tidal breathing were evaluated in 16 patients with chronic stable interstitial lung disease. Compared with those in the normal subjects, ventilation and P100 at a PCO2 = 55 mmHg were significantly higher (p less than 0.05 and p less than 0.01, respectively) in the patients with interstitial lung disease. However, the ventilatory and occlusion pressure responses to hypercapnia (delta VE/delta PCO2 and delta P 100/delta PCO2, respectively) were not significantly different between the groups. Maximal inspiratory airway pressure was significantly reduced in the patient group (p less than 0.05); maximal transdiaphragmatic pressure was also reduced but not significantly. At any given level of ventilation, tidal volume was decreased and breathing frequency increased in the patients with interstitial lung disease (p less than 0.05). The greater respiratory frequency was caused by reductions in both expiratory and inspiratory time. Because of smaller tidal volumes, rib cage expansion was reduced in the group of patients when compared with...Continue Reading

Citations

Mar 5, 2003·Clinics in Sports Medicine·Jonathon Truwit
Aug 28, 2004·Clinics in Chest Medicine·Vibha N Lama, Fernando J Martinez
Apr 9, 2014·BMC Pulmonary Medicine·Maarten K NinaberJan Stolk
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