Occlusive and reperfused myocardial infarcts: differentiation with Mn-DPDP--enhanced MR imaging

Radiology
M SaeedC B Higgins

Abstract

To assess whether the administration of manganese N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid (DPDP) permits differentiation between occlusive and reperfused infarcts, the authors subjected rats to either 6 hours of left coronary artery occlusion (n = 13) or 2 hours of occlusion followed by 4 hours of reperfusion (n = 10) before magnetic resonance (MR) imaging. Electrocardiographic-gated T1-weighted images were obtained before and for 1 hour after injection of 400 mumol/kg of Mn-DPDP. On T1-weighted images obtained before injection of Mn-DPDP. no significant differences in signal intensity were observed between normal and infarcted regions. Use of Mn-DPDP permitted delineation of the area of infarction. The pattern of enhancement in the injured zone was different for occlusive and reperfused myocardial infarcts. In rats with occlusive infarcts, In rats with occlusive infarcts, three well-defined zones were seen. Epicardium and endocardium were enhanced, while the midmyocardial zone was hypointense. The midmyocardial signal intensity gradually increased during the 60 minutes after injection. In rats with reperfused infarcts, the injured area was uniformly and intensely enhanced. Histologic examination confi...Continue Reading

Citations

Oct 24, 2006·Radiology·J Paul FinnGerhard Laub
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·M SaeedC B Higgins
May 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·M SaeedC B Higgins
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Aug 18, 2006·Basic Research in Cardiology·Timothy S E AlbertRobert M Judd
Aug 6, 2000·European Journal of Radiology·M SaeedC B Higgins
Feb 6, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Kezheng WangGregory M Lanza
Jun 16, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mayumi YamadaPhillip C Yang
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Apr 1, 1991·American Heart Journal·E E van der WallA V Bruschke
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Jun 8, 2001·Experimental Biology and Medicine·M Saeed
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·C B HigginsN Kanth
Oct 3, 2020·Biological Chemistry·Nils GumpferMichael Guckert

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