Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality

Gut
G LibbyRobert Jc Steele

Abstract

An association between detectable faecal haemoglobin (f-Hb) and both the risk of death from colorectal cancer (CRC) and all-cause mortality has been reported. We set out to confirm or refute this observation in a UK population and to explore the association between f-Hb, as indicated by a positive guaiac faecal occult blood test (gFOBT) result, and different causes of death. All individuals (134 192) who participated in gFOBT screening in Tayside, Scotland between 29/03/2000 and 29/03/2016 were studied by linking their test result (positive or negative) with mortality data from the National Records of Scotland database and following to 30/03/2016. Those with a positive test result (n=2714) had a higher risk of dying than those with a negative result, from CRC: HR 7.79 (95% CI 6.13 to 9.89), p<0.0001, (adjusted for, gender, age, deprivation quintile and medication that can cause bleeding) and all non-CRC causes: HR 1.58 (95% CI 1.45 to 1.73), p<0·0001.· In addition, f-Hb detectable by gFOBT was significantly associated with increased risk of dying from circulatory disease, respiratory disease, digestive diseases (excluding CRC), neuropsychological disease, blood and endocrine disease and non-CRC. The presence of detectable f-Hb ...Continue Reading

References

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Citations

Jan 15, 2020·World Journal of Gastroenterology : WJG·Noel Pin-Vieito On Behalf Of The Colonpredict Study Investigators
Oct 18, 2020·Nature Reviews. Gastroenterology & Hepatology·Mark A HullSara Koo
Apr 24, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Gavin R C ClarkCallum G Fraser
Sep 29, 2021·The Korean Journal of Internal Medicine·Yoon Suk JungChang Mo Moon

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