Occult cancer in women with dense breasts: detection with screening US--diagnostic yield and tumor characteristics

Radiology
T M KolbJ H Newhouse

Abstract

To evaluate bilateral screening ultrasound (US) in the detection of otherwise occult masses and cancer in women with dense breasts and normal mammographic and physical examination findings. Of 11,220 consecutive patients prospectively examined, all 3,626 women with dense breasts and normal mammographic and physical examination findings underwent physician-performed screening US. The size and stage of cancers detected with US alone were compared with those of cancers detected on mammograms, at physical examination, or both, in the remainder of the patients. In the group of 3,626 women, 11 surgically proved cancers in 11 women (prevalence, 0.30%) were identified with US alone. These cancers were not statistically significantly different in mean surgical size and stage from those of 61 nonpalpable, mammographically detected cancers and were smaller and lower in stage than 64 palpable cancers (P < .01) that were diagnosed in the remainder of the population. In the women with dense breasts, overall cancer detection increased by 17% (from 63 to 74 tumors), and the number of tumors detected only with imaging increased by 37% (from 30 to 41 tumors). Screening US can depict small, early-stage, otherwise occult cancers similar in size an...Continue Reading

Citations

Mar 10, 2005·JAMA : the Journal of the American Medical Association·Joann G ElmoreSuzanne W Fletcher
May 15, 2008·JAMA : the Journal of the American Medical Association·Wendie A BergUNKNOWN ACRIN 6666 Investigators
Apr 1, 2010·The Indian Journal of Surgery·Kalyan DasAsim Kumar Manna
Jul 4, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ayumi IzumoriAkira Sato
Feb 6, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·K Planche, S Vinnicombe
Jan 14, 2010·International Journal of Biomedical Imaging·Adam B NoverAri D Brooks
Dec 28, 1999·Lancet·D B Kopans
Mar 16, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Woo Kyung MoonJung-Gi Im
Aug 1, 2002·Medical Physics·Karen DrukkerEllen B Mendelson
Aug 9, 2003·Medical Physics·Karen DrukkerEllen B Mendelson
Aug 31, 2002·Radiology·Ferris M Hall
Feb 10, 2011·Medical Physics·Jie-Zhi ChengChung-Ming Chen
Nov 7, 1999·Radiology·H M ZonderlandA E van Voorthuisen
Dec 2, 1999·Radiology·G RahbarL W Bassett
Oct 9, 2009·Medical Physics·Ganesh NarayanasamyPaul L Carson
Feb 7, 2001·Radiology·E A Sickles
Sep 21, 2007·Medical Physics·Jia-Wei TianYing-Tao Zhang
Sep 25, 2001·Radiology·R Rosenberg, C A Kelsey
May 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K FlobbeJ M A van Engelshoven
Sep 22, 2007·La Radiologia medica·M CostantiniL Bonomo
Jul 24, 2014·AJR. American Journal of Roentgenology·Jessica M HoBradley Handler
Apr 24, 2008·European Radiology·Luc D B VercauterenKarin Flobbe
Oct 24, 2014·Radiology·Bonnie N Joe, Edward A Sickles
Jan 17, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lilian C WangEllen B Mendelson
Aug 24, 2013·Radiology·Regina J HooleyLiane E Philpotts
Sep 23, 2003·The British Journal of Radiology·S-C ChenS Hsueh
May 24, 2003·The British Journal of Radiology·A M BoschJ M A van Engelshoven
Apr 4, 2002·Radiology·Jay A Baker, Mary Scott Soo
Dec 25, 2004·Radiology·Steven P PoplackAnna N A Tosteson
Apr 2, 2003·Radiology·Wendie A BergOlga B Ioffe
Nov 1, 2002·Radiology·Valerie P Jackson

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