Occult HBV infection in anti-HBs-positive young adults after neonatal HB vaccination

Vaccine
Libin XuChunfeng Qu

Abstract

Previous follow-up on our neonatal HB vaccination cohorts with 80,000 individuals in Qidong, China, showed significant protective efficacy of immunization against HBV infection in childhood. However, some vaccinees were found to be HBsAg negative, but anti-HBs positive and anti-HBc positive at age 10-11 years. To study this phenomenon, 2919 vaccinees at age 19-21 years were sampled from the cohort. HBsAg(-), anti-HBs(+) and anti-HBc(+) were found in 124/2919 (4.2%) of the vaccinees. HBV DNA was detectable in 81/106 sample sera by using nested PCR. The PreS-S regions of HBV were sequenced in 41 randomly sampled sera. All the HBV isolates were HBV genotype C. Twenty one isolates (21/41, 51.2%) were identical to an HBV isolated in this area (GU434374). Only 4/41 (9.8%) showed mutations at the "a" epitope and three of them were G145A. The other mutations were found outside of the "a" epitope. Most of the sera contained <10,000 HBV copies/ml. Occult HBV infection happened in the young adults with HBsAg(-), anti-HBs(+) and anti-HBc(+) status, who received neonatal vaccination in Qidong.

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Citations

Apr 17, 2012·Virology Journal·Yang Yong-LinCai Xu-Bing
Feb 7, 2012·Biologicals : Journal of the International Association of Biological Standardization·Jean-Pierre AllainUNKNOWN ISBT HBV Safety Collaborative Group
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Jun 12, 2012·Journal of Hepatology·Chau-Ting Yeh, Ming-Wei Lai
Sep 24, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ling-Ling LuChunfeng Qu
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May 6, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ellie Carmody
May 6, 2016·Hepatitis Monthly·Eleanor A PowellJason T Blackard
Jun 18, 2019·The Pediatric Infectious Disease Journal·David W Scheifele
Jun 2, 2016·The American Journal of Case Reports·Purva ChhibarJen Chin Wang
Aug 23, 2020·Vaccines·Takako Inoue, Yasuhito Tanaka
Jan 29, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·An-Qun HuYing-Jie Zheng
Mar 23, 2021·Hepatology International·Ruijun WangChunfeng Qu
May 16, 2021·Microbiology and Immunology·Ashraf ElbahrawyHussein Hassan Aly

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