Abstract
Recent studies have suggested that an occult hepatitis B virus (HBV) infection negative for HBsAg but positive for HBV-DNA contributes to hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. Some follow-up studies have suggested the clinical importance of occult HBV infections in HCC development even after interferon (IFN) therapy, but a recent study denies the significance of the impact of occult HBV infection. Focusing on HCC development in patients in whom hepatitis C virus (HCV) eradication by interferon (IFN) therapy had failed, we conducted this study in order to assess the impact of occult HBV infections on HCC development in these patients. We enrolled 141 patients with chronic hepatitis C (histological stage F2 or F3) who were seropositive for HCV-RNA even after IFN therapy. Serum HBV-DNA was assayed using the real-time polymerase chain reaction. During follow-up, ultrasonography and/or computed tomography (CT) were performed at least every 6 months to monitor HCC development. The cumulative incidence rates of HCC were 8.9%, 25.7% and 53.7% at 5 years, 10 years and 15 years, respectively, after IFN therapy. Multivariate analysis indicated that low platelet counts (<12 x 10(4)/mm(3)), occult ...Continue Reading
References
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C NiederauD Häussinger
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TamoriT Kuroki
Jul 1, 1999·The New England Journal of Medicine·I CacciolaG Raimondo
Aug 14, 1999·Journal of Medical Virology·R FukudaY Kinoshita
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S PolC Bréchot
Aug 2, 2000·Journal of Gastroenterology and Hepatology·H Yatsuhashi, M Yano
Feb 15, 2001·Journal of Medical Virology·R FukudaY Kinoshita
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BréchotP Paterlini-Bréchot
Oct 5, 2001·Lancet·M P MannsJ K Albrecht
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S LokUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Aug 2, 2002·The Lancet Infectious Diseases·Michael Torbenson, David L Thomas
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 24, 2002·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Sabina MahmoodGotaro Yamada
Dec 31, 2003·Gastroenterology·Teresa PollicinoGiovanni Raimondo
Dec 31, 2003·Gastroenterology·Jorge A Marrero, Anna S F Lok
Oct 28, 2004·Gastroenterology·Kendo KiyosawaEiji Tanaka
Oct 28, 2004·Gastroenterology·Christian Bréchot
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Izumi HasegawaMasashi Mizokami
May 10, 2005·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Claudia da SilvaFernando Lopes Gonçales
Aug 17, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Chee-Kin HuiTeresa Lyn Wright
Feb 3, 2006·Cancer·Giovanni SquadritoGiovanni Raimondo
May 2, 2007·Annals of Internal Medicine·Kazuki IkedaTsutomu Chiba
Citations
Oct 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Peiman HabibollahiSeyed M Alavian
Mar 16, 2011·European Journal of Internal Medicine·Heba S SelimAhmed F Bakry
Jan 17, 2009·Cancer Letters·I Chemin, F Zoulim
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S LokUNKNOWN HALT-C Trial Group
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Yu ShiZhi Chen
Jan 21, 2014·Journal of Viral Hepatitis·X Huang, F B Hollinger
Jun 12, 2013·Journal of Hepatology·Giovanni SquadritoGiovanni Raimondo
Oct 23, 2012·Hepatitis Monthly·Seyed Moayed AlavianSeyed Mohammad Jazayeri
Mar 27, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cecilia M DelfinoMirna M Biglione
Sep 8, 2010·The Journal of International Medical Research·H QinY Ma
Jul 30, 2016·Medicine·Nicola CoppolaItalo F Angelillo
Oct 1, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jae Young Jang, Eui Ju Park
May 3, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Katsuaki Tanaka
Jul 22, 2010·Journal of Medical Virology·Sonia RomanArturo Panduro
Feb 20, 2010·Expert Opinion on Pharmacotherapy·Andrej PotthoffHeiner Wedemeyer
Oct 10, 2012·European Journal of Gastroenterology & Hepatology·Claudia CardosoAna P Oliveira
Apr 11, 2020·Journal of Medical Virology·Mariantonietta PisaturoNicola Coppola
Aug 30, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ryoichi GotoYoshihiko Maehara
Dec 30, 2014·World Journal of Hepatology·Min-Sun Kwak, Yoon Jun Kim
Nov 30, 2016·World Journal of Gastroenterology : WJG·Junhyeon ChoSook-Hyang Jeong
Nov 18, 2015·World Journal of Gastroenterology : WJG·Nicola CoppolaEvangelista Sagnelli
Jun 7, 2020·Journal of Hepatology·Lung-Yi MakMan-Fung Yuen