Occult hepatitis B virus infection in Chinese cryptogenic intrahepatic cholangiocarcinoma patient population

Journal of Clinical Gastroenterology
YuQiong LiHePing Hu

Abstract

There is no information available about occult hepatitis B virus (HBV) infection (OBI) in individuals with intrahepatic cholangiocarcinoma (ICC). To investigate the correlation between OBI and ICC. A retrospective case-control study was conducted. The cases were 183 cryptogenic ICC patients (group I), and the controls were 549 healthy individuals (group II). The cases and controls were matched for age, sex, and inhabitancy. Adjusted odds ratios and 95% confidence intervals were calculated. Intrahepatic total HBV DNA in 63 paraffin-embedded samples was collected from patients in group I (n=44), HBV-associated ICC patients (n=3), and hepatic cavernous hemangioma patients with seronegative HBsAg (hepatitis B S antigen) (group III; n=16). We determined the levels of serum and intrahepatic HBV DNA and compared the level of intrahepatic HBV DNA in 44 cryptogenic patients from group I with the level in the patients from group III. Compared with group II, group I had a lower prevalence of anti-HBs (antibody against HBsAg) and a higher prevalence of anti-HBe (antibody against hepatitis B e antigen) and anti-HBc (antibody against hepatitis B c antigen). Multivariate analysis confirmed that anti-HBe and anti-HBc positivity were associated...Continue Reading

References

Jul 1, 1999·The New England Journal of Medicine·I CacciolaG Raimondo
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N ChalasaniH Hoen
Jun 26, 2002·Journal of Viral Hepatitis·Ke-Qin Hu
Aug 2, 2002·The Lancet Infectious Diseases·Michael Torbenson, David L Thomas
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Man-Fung YuenChing-Lung Lai
Mar 15, 2005·Gastroenterology·Yasser H ShaibKatherine A McGlynn
Nov 23, 2006·Journal of Hepatology·Giovanni RaimondoGiovanni Squadrito
Oct 30, 2007·World Journal of Gastroenterology : WJG·Patricia M Mulrooney-Cousins, Tomasz I Michalak
Mar 4, 2008·Journal of Hepatology·Giovanni RaimondoTeresa Pollicino
Aug 22, 2008·Journal of Hepatology·Giovanni RaimondoFabien Zoulim
Jan 17, 2009·Cancer Letters·I Chemin, F Zoulim
Dec 17, 2009·Journal of Viral Hepatitis·F B Hollinger, G Sood
Mar 6, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Huabang ZhouHeping Hu
Mar 23, 2010·Pathologie-biologie·G RaimondoA R Zanetti
Apr 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria Stella De MitriMauro Bernardi
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chyng-Wen FwuChien-Jen Chen
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.