Occupational allergic contact dermatitis caused by 2,4,6-tris-(dimethylaminomethyl)phenol, and review of sensitizing epoxy resin hardeners

International Journal of Dermatology
L KanervaR Jolanki

Abstract

Epoxy resin compounds (ERC) include a large number of sensitizing chemicals such as epoxy resins (ER), hardeners (curing agents), and reactive diluents. Allergic contact dermatitis (ACD) caused by ERCS is often occupational. We report a patient, sensitized to a hardener of a two-component epoxy paint. Three conventional patch test sessions were performed to diagnose the causative chemical. We also review the literature on sensitizing epoxy-resin hardeners. A 47-year-old nonatopic woman developed dermatitis from a two-component epoxy paint. Patch testing with epoxy resin was negative, but 2,4,6-tris(dimethylaminomethyl)phenol (tris-DMP), used in the paint hardener, induced an allergic patch test reaction. We also review briefly other epoxy hardeners that have caused allergic dermatitis, including: (1) aliphatic polyamines, e.g., ethylenediamine, diethylenetriamine, triethylenetetramine, 3-dimethylaminopropylamine, and trimethylhexamethylenediamine; (2) cycloaliphatic polyamines, e.g., isophoronediamine and 3,3'-dimethyl-4,4-diaminodicyclohexylmethane; (3) aromatic amines, such as 4,4'-diaminodiphenylmethane, m-phenylene diamine, and 1,3-xylylene diamine; (4) dicyanodiamide; (5) triglycidyl isocyanurate, an epoxy compound that ma...Continue Reading

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Citations

Aug 12, 1999·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·C GallagherR Brancaccio
Jan 1, 1997·Contact Dermatitis·L KanervaT Estlander
Jul 8, 2009·Dermatologic Clinics·Lauren Y CaoJames S Taylor
Jul 11, 2012·Contact Dermatitis·Johannes GeierThomas Fuchs
Jul 6, 2014·Contact Dermatitis·Kristiina Aalto-KorteRiitta Jolanki
Oct 12, 1999·International Journal of Dermatology·C Géraut, D Tripodi
Aug 22, 2006·Contact Dermatitis·Olve RømyhrHans Thore Smedbold
Apr 16, 1998·Contact Dermatitis·L Kanerva, T Estlander
Jul 17, 1998·Contact Dermatitis·R Brooke, M H Beck
Feb 24, 2001·Contact Dermatitis·R JolankiL Kanerva

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