Occupational and environmental hazard assessments for the isolation, purification and toxicity testing of cyanobacterial toxins.

Environmental Health : a Global Access Science Source
Ian StewartG Shaw

Abstract

Cyanobacteria can produce groups of structurally and functionally unrelated but highly potent toxins. Cyanotoxins are used in multiple research endeavours, either for direct investigation of their toxicologic properties, or as functional analogues for various biochemical and physiological processes. This paper presents occupational safety guidelines and recommendations for personnel working in field, laboratory or industrial settings to produce and use purified cyanotoxins and toxic cyanobacteria, from bulk harvesting of bloom material, mass culture of laboratory isolates, through routine extraction, isolation and purification. Oral, inhalational, dermal and parenteral routes are all potential occupational exposure pathways during the various stages of cyanotoxin production and application. Investigation of toxicologic or pharmacologic properties using in vivo models may present specific risks if radiolabelled cyanotoxins are employed, and the potential for occupational exposure via the dermal route is heightened with the use of organic solvents as vehicles. Inter- and intra-national transport of living cyanobacteria for research purposes risks establishing feral microalgal populations, so disinfection of culture equipment and ...Continue Reading

References

Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·S P HawserE J Carpenter
Jun 2, 1990·BMJ : British Medical Journal·P C TurnerG A Codd
Sep 1, 1985·Journal of Medicinal Chemistry·A M Koskinen, H Rapoport
Mar 18, 1999·Toxicon : Official Journal of the International Society on Toxinology·D AndrinoloN Lagos
Dec 28, 1999·Gynecologic and Obstetric Investigation
Sep 9, 2000·Toxicon : Official Journal of the International Society on Toxinology·E ItoK Harada
Oct 31, 2000·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·I ChorusJ Bartram
Jan 5, 2002·Environment International·N J OsborneG R Shaw
Jan 5, 2002·Environmental Toxicology·R L NorrisM R Moore
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Carlos GarcíaNéstor Lagos
Apr 5, 2005·Toxicon : Official Journal of the International Society on Toxinology·Janet M BensonLora E Fleming
Jun 16, 2005·Environmental Science & Technology·Yung Sung ChengDaniel G Baden
Jul 2, 2005·The Journal of Organic Chemistry·Thomas HjelmgaardDavid Tanner
May 19, 2007·Toxicon : Official Journal of the International Society on Toxinology·Ian R Falconer
Jul 31, 2007·Journal of the American Chemical Society·James J FlemingJ Du Bois
Oct 9, 2007·Journal of Hazardous Materials·Ruihua DaiYining Hou
Oct 11, 2007·Angewandte Chemie·Osamu IwamotoKazuo Nagasawa
Feb 12, 2008·Current Protocols in Molecular Biology·Douglas C Weiser, Shirish Shenolikar
May 9, 2008·Advances in Experimental Medicine and Biology·Rex A PegramRobert Thacker
May 9, 2008·Advances in Experimental Medicine and Biology·Sandra M F O AzevedoJohn W Fournie
May 9, 2008·Marine Drugs·Yung Sung ChengLorraine C Backer
May 27, 2008·The Science of the Total Environment·Barbara KirkpatrickGary Kirkpatrick
Dec 17, 2008·Environmental Health : a Global Access Science Source·Edward A LawsJohn J Stegeman

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Citations

Aug 2, 2012·International Journal of Environmental Research and Public Health·Glenn B McGregorWasa Wickramasinghe
Mar 26, 2014·Environmental Monitoring and Assessment·Judita KoreivienėVilma Burškytė
Nov 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alejandro M S MayerPhillip Williams
Feb 21, 2014·Journal of Environmental Sciences (China)·Xuetang LuJun Xie
Jun 22, 2012·PloS One·Andrew M DolmanClaudia Wiedner

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