Abstract
Pesticides are a complex mixture of chemicals used to protect crops from a number of pests and diseases. They have been considered as potential mutagenic agents. This study aims at evaluation of the mutagenic effect of pesticide exposure to agricultural workers through chromosomal aberrations (CA) and micronucleus (MN) assay in peripheral blood lymphocytes and oral mucosal cells, respectively. The exposed group was consisted with 97 farmers, while the control (un-exposed) group consisted of 55. The results showed a significant (p < 0.05) increase in frequency of CA and MN in the exposed group. Both CA and MN profiles were linked to a significant (p < 0.05) co-relation with the confounding factors such as smoking habits, alcohol, vegetables, tea/coffee, vitamins, and sweetener consumptions. More cytogenetic events were denoted in smoking and alcohol consumption as well as non-personal protective equipment (non-PPE) and low/no vegetables user farmers. In conclusion, a deficiency of dietary and medicaments-derived antioxidants, while consumption of alcohol and tobacco, as well as effects of radiation, heavy metal poisoning (especially from sweeteners), and non-PPE using habits, may contribute cytogenetic damage to the workers.
References
Mar 1, 1988·Mutation Research·A V Carrano, A T Natarajan
May 1, 1997·American Journal of Industrial Medicine·J E Keller-ByrneE A Schaub
Aug 31, 2002·Mutagenesis·Claudia BolognesiEleonora Landini
May 3, 2003·American Journal of Epidemiology·Michael C R AlavanjaAaron Blair
Jun 6, 2003·Mutation Research·Claudia Bolognesi
Sep 1, 1960·Experimental Cell Research·P S MOORHEADD A HUNGERFORD
Jan 1, 2005·Environmental Health Perspectives·Anneclaire J De RoosMichael C Alavanja
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Yingshuai LiuJianwei Mo
Aug 5, 2006·Mutation Research·N SailajaParamjit Grover
Sep 19, 2006·Mutagenesis·Carla CostaOlga Mayan
Oct 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vipul K SinghM K J Siddiqui
Apr 10, 2007·Mutation Research·Radim J SramPeter B Farmer
Mar 17, 2009·Chemical Research in Toxicology·John E Casida
Jan 29, 2010·Journal of Toxicology·Sahdeo PrasadYogeshwer Shukla
Jul 19, 2011·Mutation Research·Stefano BonassiMichael Fenech
Jan 26, 2013·Mutation Research·Danieli BenedettiJuliana da Silva
Feb 16, 2013·Genetics and Molecular Biology·Katia KvitkoJuliana da Silva
Apr 11, 2013·PloS One·Mari FujitaKouji Hirota
May 28, 2013·International Journal of Hygiene and Environmental Health·Afifa KausarAnirudha Giri
Nov 2, 2013·Interdisciplinary Toxicology·Nazia NazamWaseem Ahmad
Apr 2, 2014·Genetics and Molecular Biology·Carlos Alvarez-MoyaAlfredo Feria Velasco
Aug 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Hai-Yan YangYa-Dong Wang
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zakerinia MaryamMehrabani Davood
Mar 12, 2015·Journal of Occupational Medicine and Toxicology·Avinash Shivaji GaikwadRavichandran Beerappa
Feb 27, 2016·Chemosphere·Hongwei HuYiming Yao
Aug 10, 2016·Journal of Clinical and Diagnostic Research : JCDR·Mallika Bokka Sri Satya NagaSangameshwar Manikya