Occupational asthma caused by metal arc welding of iron

Respiration; International Review of Thoracic Diseases
Xavier MuñozFerran Morell


Epidemiological studies have shown that exposure to welding fumes can be a cause of occupational asthma (OA), although the mechanisms implicated are unknown. We describe 3 patients (all men, mean age 42 years) with OA secondary to exposure to welding fumes generated during metal arc welding on iron. The exposure time ranged from 7 to 43 years and the time of the onset of symptoms following the start of exposure was 2-12 years. Patients were diagnosed by specific inhalation challenge (SIC). Environmental levels of Fe, Cd, Cu, Cr, Ni, NO2, NO, CO, and O3 produced during the SIC did not exceed threshold limit values. Samples of induced sputum were obtained before and after the SIC and showed an increase in neutrophils and concentrations of IL-8, TNF-α and TNF-β after the SIC. This study presents the first clinical findings reported in welders with OA, mainly working with iron. Neutrophilic inflammation seems to play a role in this disease.


May 2, 2012·Journal of Allergy·J A PralongM Labrecque
Aug 30, 2012·Clinics in Chest Medicine·Catherine LemiereJacques-André Pralong
Oct 8, 2011·Immunology and Allergy Clinics of North America·Santiago Quirce, Jonathan A Bernstein
Jul 15, 2011·The Journal of Allergy and Clinical Immunology·Øyvind OmlandTorben Sigsgaard
Jun 26, 2012·International Journal of Occupational Medicine and Environmental Health·Tomasz WittczakCezary Pałczyński
Nov 20, 2014·International Archives of Occupational and Environmental Health·Pernille KristiansenJens Peter Bonde
Mar 17, 2011·Journal of Occupational and Environmental Medicine·Amit BangaKenneth D Rosenman
Mar 4, 2011·Current Opinion in Allergy and Clinical Immunology·Santiago Quirce, Joaquín Sastre

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