PMID: 9179424May 1, 1997Paper

Occupational asthma caused by triglycidyl isocyanurate (TGIC)

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
P PiiriläH Nordman

Abstract

Polyester powder paints are extensively used in metal painting. Triglycidyl isocyanurate (TGIC), an epoxy compound, is often used as a hardener. Several cases of allergic eczema from occupational exposure to TGIC have been reported in the literature. We examined a 36-year-old non-smoking man who worked mainly as a spray painter, using a polyester powder paint containing 4% TGIC. During painting he used protective clothing and a motorized breathing protector. After 4 years he developed eczema on his hands, face and body, and an occupational allergic eczema caused by TGIC was diagnosed. He also suffered from powder-paint-related asthmatic symptoms. Occupational asthma was diagnosed in accordance with the accepted guidelines. Inhalation challenge tests were performed with the paint and TGIC. Spirometry showed slight obstruction; the blood eosinophils and serum IgE value were elevated. Skin-prick tests with common environmental allergens were negative. The challenge test with lactose powder was also negative. A challenge test with a paint containing TGIC (4%) induced a dual reaction in PEF and a late 23% fall in FEV1. A test with TGIC (4%) mixed with lactose induced a dual PEF reaction, and also dual changes in spirometry. The PD15...Continue Reading

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Citations

Aug 19, 2010·International Archives of Occupational and Environmental Health·Joaquín SastreMar Fernández-Nieto
Nov 3, 2010·Occupational Medicine·W AneesP S Burge
Feb 24, 2005·International Archives of Occupational and Environmental Health·Anna BlomqvistHans Welinder
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P RuoppiA Taivainen

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