PMID: 7489809Aug 1, 1995Paper

Occupational asthma due to ceftazidime

The European Respiratory Journal
S C StentonD J Hendrick

Abstract

A worker employed in the manufacture of the new third generation cephalosporin antibiotic, ceftazidime, developed asthmatic symptoms, and a series of inhalation challenge tests was undertaken to investigate the problem. The inhalation of increasing daily doses of ceftazidime up to 3.2 mg, using a double-blind challenge protocol gave rise to symptoms, late asthmatic reactions, and increases in airway responsiveness to methacholine. A repeat challenge with the 3.2 mg dose additionally gave rise to a clear immediate reaction. Ceftazidime was, thus, shown to be capable of inducing occupational asthma.

Citations

May 6, 2010·Chest·Susana Gómez-OllésXavier Muñoz
May 24, 2011·Journal of Allergy·Sara Díaz AnguloPaul Cullinan
Jan 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BlancaA DeWeck
Apr 29, 2004·The Journal of Allergy and Clinical Immunology·Hae-Sim ParkChoon-Sik Park
Jul 31, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sander DikJanine Ezendam
Oct 13, 2009·Chronic Respiratory Disease·S C Stenton
Apr 5, 2011·Allergy, Asthma & Immunology Research·Hyun Jung JinHae-Sim Park
Jul 14, 2000·American Journal of Industrial Medicine·V van KampenX Baur
Nov 9, 2017·American Journal of Industrial Medicine·Rolf MergetThomas Brüning

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