PMID: 6162800Jan 1, 1981Paper

Occupational asthma due to inhalation of chloramine-T. II. Demonstration of specific IgE antibodies

International Archives of Allergy and Applied Immunology
J A KrampsJ H Dijkman

Abstract

In the sera of patients who developed asthmatic symptoms after exposure to chloramine-T, specific IgE antibodies are demonstrated by a polystyrene tube radioimmunoassay. These antibodies are directed against human serum albumin treated with chloramine-T. Specific antibodies of subclasses IgG1, IgG3 and IgG4 were not found. Histamine release in response to chloramine-T-treated human serum albumin was demonstrated using the peripheral blood leukocytes of one of the patients. To define the antigenic determinant to which the specific IgE antibodies are directed, radioimmunoassay and radioimmunoassay-inhibition studies were performed using several autologous and heterologous chloramine-T-treated proteins. Moreover, the inhibition capacities of chloramine-T and structurally related compounds were also determined. The results of these experiments indicate that the antigenic determinant is formed, at least in part, by the p-toluenesulfonyl group of the chloramine-T molecule.

Citations

Jan 1, 1991·International Archives of Occupational and Environmental Health·A M BlomqvistO Zetterström
Jul 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U WassN E Eriksson
Jul 14, 2000·American Journal of Industrial Medicine·V van KampenX Baur
Sep 27, 2012·Journal of Medical Case Reports·Simona D'AlòStefano Pucci
Apr 1, 1989·Contact Dermatitis·P LombardiA Sertoli
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine
Jul 1, 1983·Contact Dermatitis·A Dooms-GoossensD Vanderheyden
Feb 12, 1998·Contact Dermatitis·L KanervaR Jolanki
May 21, 2014·International Journal of Occupational Medicine and Environmental Health·Agnieszka Lipińska-OjrzanowskaJolanta Walusiak-Skorupa
Feb 20, 2016·Archives of Environmental & Occupational Health·Agnieszka Anna Lipinska-OjrzanowskaJolanta Magdalena Walusiak-Skorupa
Jan 1, 1996·Occupational and Environmental Medicine·G DoekesA Hollander
Nov 20, 2019·Allergy, Asthma & Immunology Research·Agnieszka Lipińska-OjrzanowskaJolanta Walusiak-Skorupa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

International Archives of Occupational and Environmental Health
A M BlomqvistO Zetterström
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
U WassN E Eriksson
Clinica Chimica Acta; International Journal of Clinical Chemistry
G BonoraG Labò
Journal of Physiology, Paris
J M Garel, J P Barlet
© 2021 Meta ULC. All rights reserved