Occupational asthma induced by cephalosporins

The European Respiratory Journal
J SastreA Umpiérrez

Abstract

A 20-yr-old pharmaceutical worker who developed attacks of shortness of breath and wheezing 9 months after beginning work on a process in which cefadroxil powder was bottled or encapsulated will be described. Skin test with cefaxodril was negative. Baseline spirometry and methacholine inhalation test were normal. A controlled bronchial challenge test was carried out in a closed-circuit system with assessment of respirable dust concentration. Exposure to cefadroxil powder at a mean concentration of 10 mg x m(-3) for 10 min elicited an isolated immediate asthmatic response, but no response was observed to control challenge with lactose. Single-blind oral challenge test with amoxicillin up to 500 mg was well tolerated, whereas the oral challenge with cephalexin (25 mg) elicited an immediate asthmatic response. This patient had developed occupational asthma caused by inhalation of cefadroxil as confirmed by specific inhalation test. Since she tolerated oral amoxicillin, a synthetic penicillin with the side-chain identical to that of cefadroxil, it seems that she may be sensitized to the dihydrothiazine ring of cephalosporins.

Citations

Aug 29, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Santiago QuirceJoaquín Sastre
Jul 9, 2004·Clinical and Experimental Pharmacology & Physiology·S OtoomN Najib
May 8, 2003·Journal of Toxicology. Clinical Toxicology·Michael L GreenbergAllison A Muller
May 6, 2010·Chest·Susana Gómez-OllésXavier Muñoz
May 24, 2011·Journal of Allergy·Sara Díaz AnguloPaul Cullinan
Nov 8, 2003·Chest·Hanifi KurtaranZekai Avci
Apr 29, 2004·The Journal of Allergy and Clinical Immunology·Hae-Sim ParkChoon-Sik Park
Oct 19, 2004·American Journal of Industrial Medicine·Eugenija ZuskinIskra A Nola-Premec
Nov 21, 2012·Journal of Korean Medical Science·Young-Hee NamHae-Sim Park
Nov 9, 2017·American Journal of Industrial Medicine·Rolf MergetThomas Brüning

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