Occupational contact dermatitis from propacetamol

Contact Dermatitis
C SzczurkoD Leroy

Abstract

We report 4 cases of contact sensitization to propacetamol. They presented with lesions on the hands, forearms, crease of the elbows, and neck. They were all sensitized to multiple allergens and 2 of them were atopic. Patch tests to Pro-Dafalgan and propacetamol were positive; sodium citrate and paracetamol were negative. Our cases were similar to those published for the first time by Barbaud in 1995. The only allergen was propacetamol; patch tests with diethyglycine and paracetamol were negative. Propacetamol chlorhydrate is composed of a complex paracetamol-diethylglycine, which probably acts like a hapten capable of inducing cutaneous allergy. It is an occupational allergy affecting nurses who work in surgery departments or post-anesthesia recovery rooms, where high doses of analgesics are widely used. The patients were not allergic to oral paracetamol. Despite the usual precautions, the mixture of propacetamol chlorhydrate and solvent leaks onto the nurses' hands, suggesting that health care workers handling propacetamol chlorhydrate should wear gloves.

References

Sep 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R LeungD Czarny
Jul 1, 1992·Journal of the American Academy of Dermatology·D AbeckJ Ring
Sep 30, 1995·Lancet·A BarbaudJ L Schmutz
Jan 1, 1993·Developmental Pharmacology and Therapeutics·E AutretJ Laugier

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Citations

Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Jun 26, 2001·Contact Dermatitis·P D Yesudian, C M King
May 1, 1997·Contact Dermatitis·P Mathelier-FusadeF Leynadier
Nov 28, 2001·Contact Dermatitis·K Gielen, A Goossens
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Stephan A Schug, Andreas Manopas
Mar 22, 2001·Contact Dermatitis·T EstlanderL Kanerva

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