Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women's Health Study.

Environmental Health Perspectives
Bryan BassigQing Lan

Abstract

The association between benzene exposure and non-Hodgkin lymphoma (NHL) has been the subject of debate as a result of inconsistent epidemiologic evidence. An International Agency for Research on Cancer (IARC) working group evaluated benzene in 2009 and noted evidence for a positive association between benzene exposure and NHL risk. We evaluated the association between occupational benzene exposure and NHL among 73,087 women enrolled in the prospective population-based Shanghai Women's Health Study. Benzene exposure estimates were derived using a previously developed exposure assessment framework that combined ordinal job-exposure matrix intensity ratings with quantitative benzene exposure measurements from an inspection database of Shanghai factories collected between 1954 and 2000. Associations between benzene exposure metrics and NHL (n = 102 cases) were assessed using Cox proportional hazard models, with study follow-up occurring from December 1996 through December 2009. Women ever exposed to benzene had a significantly higher risk of NHL [hazard ratio (HR) = 1.87, 95% CI: 1.19, 2.96]. Compared with unexposed women, significant trends in NHL risk were observed for increasing years of benzene exposure (p(trend) = 0.006) and i...Continue Reading

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Citations

Sep 8, 2017·Disaster Medicine and Public Health Preparedness·Mark A D'Andrea, G Kesava Reddy
Jun 1, 2020·American Journal of Industrial Medicine·Martha S LinetNathaniel Rothman
Nov 26, 2016·Occupational and Environmental Medicine·Marcel GoldbergUNKNOWN CONSTANCES team
Aug 28, 2020·Cancer Causes & Control : CCC·Michael K OdutolaClaire M Vajdic
Feb 23, 2020·Environmental Health : a Global Access Science Source·Jie LiMaigeng Zhou
Sep 11, 2019·Annals of Work Exposures and Health·Pamela J DopartMelissa C Friesen
Aug 28, 2021·The Lancet. Planetary Health·Iemaan RanaLuoping Zhang

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