Occupational exposure to dusts and risk of renal cell carcinoma.

British Journal of Cancer
S KaramiL E Moore

Abstract

Occupational exposures to dusts have generally been examined in relation to cancers of the respiratory system and have rarely been examined in relation to other cancers, such as renal cell carcinoma (RCC). Although previous epidemiological studies, though few, have shown certain dusts, such as asbestos, to increase renal cancer risk, the potential for other occupational dust exposures to cause kidney damage and/or cancer may exist. We investigated whether asbestos, as well as 20 other occupational dust exposures, were associated with RCC risk in a large European, multi-center, hospital-based renal case-control study. General occupational histories and job-specific questionnaires were reviewed by occupational hygienists for subject-specific information. Odds ratios (ORs) and 95% confidence intervals (95% CIs) between RCC risk and exposures were calculated using unconditional logistic regression. Among participants ever exposed to dusts, significant associations were observed for glass fibres (OR: 2.1; 95% CI: 1.1-3.9), mineral wool fibres (OR: 2.5; 95% CI: 1.2-5.1), and brick dust (OR: 1.5; 95% CI: 1.0-2.4). Significant trends were also observed with exposure duration and cumulative exposure. No association between RCC risk and ...Continue Reading

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Citations

Mar 22, 2016·Scandinavian Journal of Urology·Elin MariusdottirTomas Gudbjartsson
Mar 23, 2018·Inhalation Toxicology·L Daniel Maxim, Mark J Utell
Feb 1, 2013·Current Urology·Tahir QayyumJoanne Edwards
Aug 4, 2016·Occupational and Environmental Medicine·Deepika ShresthaKatie M Applebaum
Oct 22, 2013·Occupational and Environmental Medicine·Yuriko IwatsuboEllen Imbernon

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