PMID: 6160111Jan 1, 1980Paper

Occupational exposure to hexachlorocyclohexane. I. Body burden of HCH-isomers

International Archives of Occupational and Environmental Health
K BaumannG Lehnert

Abstract

In a lindane (gamma-hexachlorocyclohexane = gamma-benzenehexachloride)-producing factor 57 workers were studied with regard to their blood levels of the three hexachlorocyclohexane isomers: alpha-, beta-, and gamma-HCH. The TLV-TWA (MAK value 1979) for gamma-HCH of 0.5 mg/m3 was not exceeded at any of the workplaces where HCH is synthesized and purified to lindane. Additionally, in some of the workers samples of s.c. adipose tissue were taken for determination of HCH-isomer content. An external group of 20 clerks was examined in the same way for control purposes. In contrast to the control persons, none of whom had HCH-concentrations in serum above the respective detection limits, the values determined in serum of the exposed workers were in the following ranges: alpha-HCH: 10-273 microgram/1, beta-HCH: 17-760 microgram/l, and gamma-HCH: 5-188 microgram/1. Of special interest is the observation of a significant increase of beta-HCH-concentration in serum with the time of employment in lindane production, indicating a pronounced accumulation of this substance in the human organism. Concentrations of this isomer in s.c. adipose tissues were about 300-fold higher than in serum. A significant correlation between both parameters cou...Continue Reading

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Citations

May 1, 1991·Bulletin of Environmental Contamination and Toxicology·K SasakiM Uchiyama
Jan 1, 1986·International Archives of Occupational and Environmental Health·S K NigamB B Chatterjee
Jul 1, 1988·British Journal of Industrial Medicine·L DrummondH K Wilson
Jul 24, 2001·Drugs·T C RoosD R Bickers
Jan 1, 1981·International Archives of Occupational and Environmental Health·S TomczakG Lehnert
Jan 1, 1993·International Archives of Occupational and Environmental Health·S K NigamS K Kashyap
Jan 1, 1981·International Archives of Occupational and Environmental Health·H L BrassowG Lehnert
Jan 14, 1998·Human & Experimental Toxicology·I P DickF M Williams
Jan 1, 1983·International Archives of Occupational and Environmental Health·J AngererR Heinrich
Jan 20, 2020·Neurotoxicity Research·Jolene KokrokoBrenda Eskenazi
Feb 1, 1990·Journal of Clinical Pathology·F P Rugman, R Cosstick
Feb 1, 1982·International Archives of Occupational and Environmental Health·M S WolffI J Selikoff
May 1, 1997·Journal of Toxicology and Environmental Health·D JungO Päpke
May 20, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rita Loch CarusoJames E Trosko
Jan 1, 1990·Immunopharmacology and Immunotoxicology·S N DasP K Ray
Jan 1, 1988·Annals of the New York Academy of Sciences·S K NigamB H Joshi
Jan 1, 1981·International Archives of Occupational and Environmental Health·K BaumannK Stapel
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rita Loch-CarusoJames E Trosko
Sep 2, 2014·International Journal of Environmental Research and Public Health·Abdulaziz Al-OthmanNasser M Al-Daghri
Jan 1, 1995·Toxicology Letters·S C SrivastavaS P Srivastava

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