Occupational exposure to low levels of benzene: Biomarkers of exposure and nucleic acid oxidation and their modulation by polymorphic xenobiotic metabolizing enzymes

Toxicology Letters
Paola ManiniAntonio Mutti

Abstract

This study investigated nucleic acid oxidation associated with exposure to benzene at low levels in 239 workers recruited among traffic policemen, taxi drivers and gasoline pump attendants of the city of Parma (Italy). Biomarkers of exposure, namely urinary t,t-muconic acid (t,t-MA) and S-phenylmercapturic acid (S-PMA), urinary cotinine, and urinary biomarkers of nucleic acid oxidation, namely 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydroguanine (8-oxoGua) were determined by liquid chromatography-tandem mass spectrometry. Relevant polymorphisms of NAD(P)H:quinone oxidoreductase (NQO1), glutathione S-transferases M1-1 (GSTM1), T1-1 (GSTT1), and A1 (GSTA1) were characterized by polymerase chain reaction-based methods in a subgroup of subjects. Biomarkers of nucleic acid oxidation were correlated with each other (r> or =0.32, p<0.0001) and with exposure biomarkers (r> or =0.28, p<0.0001). Multiple linear regression models including age, sex and smoking habits as independent variables demonstrated that benzene exposure is associated with oxidation damage to nucleic acid, particularly to RNA (p<0.0001) and is modulated by the NQO1 polymorphism. The study confirmed a sign...Continue Reading

References

Mar 1, 1996·American Journal of Industrial Medicine·N RothmanR B Hayes
Oct 1, 1996·Mutation Research·L LiuW Zhang
Oct 26, 2000·Environmental Health Perspectives·UNKNOWN World Health Organization
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·T TsuzukiM Sekiguchi
Jun 12, 2003·The Science of the Total Environment·Mette SørensenSteffen Loft
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Mar 3, 2004·Archives of Biochemistry and Biophysics·Andrew R CollinsJose Viña
Apr 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mark D Evans, Marcus S Cooke
Jun 7, 2005·Chemico-biological Interactions·Qingshan QuRuidong Mu
Jun 7, 2005·Chemico-biological Interactions·Roberto BonoGiorgio Gilli
Sep 1, 2005·Cancer Science·Masahiro IrieHiroshi Kasai
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Silvia FustinoniDomenico F Merlo
Nov 18, 2005·Toxicology Letters·Mariella CarrieriGiovanni Battista Bartolucci
Apr 26, 2006·Basic & Clinical Pharmacology & Toxicology·Shingo KimuraKeiki Ogino
May 11, 2006·International Archives of Occupational and Environmental Health·A Pilger, H W Rüdiger
Oct 19, 2006·Journal of Biomedicine & Biotechnology·Akihiko NunomuraGeorge Perry
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sungkyoon KimStephen M Rappaport
Feb 6, 2007·Free Radical Biology & Medicine·Parul R PatelJoseph Lunec
Sep 22, 2007·Pharmacogenetics and Genomics·Sungkyoon KimStephen M Rappaport
Feb 20, 2008·Chemico-biological Interactions·Nantaporn ButhbumrungMathuros Ruchirawat
Jul 22, 2008·Toxicology Letters·Paola ManiniPietro Apostoli
May 12, 2009·Toxicology Letters·Maria Enrica FracassoMaurizio Manno
May 19, 2009·Environmental and Molecular Mutagenesis·George BarretoLisandro Diego Alvarez-Giraldez

❮ Previous
Next ❯

Citations

Oct 26, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Gabriela GöethelSolange C Garcia
May 31, 2012·Journal of Health Care for the Poor and Underserved·Funmi Apantaku-OnayemiDaniel S Blumenthal
Jun 7, 2012·Neurotoxicity Research·Akihiko NunomuraGeorge Perry
Dec 10, 2015·Environmental and Molecular Mutagenesis·Piero LovreglioLeonardo Soleo
Nov 16, 2010·Free Radical Biology & Medicine·Roberta AndreoliGiuseppe De Palma
Nov 12, 2015·Chemico-biological Interactions·Adam T ZarthStephen S Hecht
Mar 31, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Giuseppe De PalmaAntonio Mutti
Aug 2, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Evan O GreggMichael McEwan
May 30, 2015·Toxicology Letters·Massimiliano MascelloniRoy M Harrison
Nov 3, 2011·Free Radical Biology & Medicine·Steffen LoftOle Raaschou-Nielsen
Nov 5, 2013·Chemosphere·Mireille BorgieZeina Dagher
Jun 27, 2014·Toxicology Letters·Damiano CarbonariAntonella Mansi
Jul 22, 2015·International Journal of Environmental Research and Public Health·Simone MitriPaula de Novaes Sarcinelli
Oct 21, 2017·Biomarkers in Medicine·Pieranna ChiarellaGiovanna Tranfo
Jan 10, 2019·International Journal of Environmental Research and Public Health·Mariella CarrieriGiovanna Tranfo
Mar 23, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Silvia FustinoniPier Alberto Bertazzi
Jul 29, 2010·Critical Reviews in Toxicology·Gary GinsbergBabasaheb Sonawane
May 5, 2012·Journal of Environmental Monitoring : JEM·Ciarrocca ManuelaSancini Angela
Jan 1, 2017·Bulletin of Environmental Contamination and Toxicology·Veerapas Na Roi-EtChart Chiemchaisri
Jul 31, 2020·Environmental Science and Pollution Research International·Chi-Jung ChungHui-Ling Lee
Apr 19, 2017·Environmental Science and Pollution Research International·Hassan R DhainiCharbel Afif
Aug 10, 2020·Environmental Science and Pollution Research International·Mehdi MoridzadehMohammad Hoseini
Jul 24, 2021·Health Science Reports·Verónica Ramírez-LoperaTania Liseth Pérez-Cala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.