Occupational exposure to platinum drugs during intraperitoneal chemotherapy. Biomonitoring and surface contamination

Toxicology Letters
S NdawN Bakrin

Abstract

Hyperthermic intraperitoneal chemotherapy (HIPEC) has been introduced over the last decade for the treatment of peritoneal carcinomatosis. In this procedure, heated cytotoxic drugs are administered directly into the abdominal cavity, ensuring cancer cells to be exposed while reducing systemic toxicity. More recently, pressurized intraperitoneal aerosol chemotherapy (PIPAC), where the chemotherapeutic drug is injected into the peritoneal cavity as an aerosol under pressure, has been proposed to patients in palliative situation, as a new approach. The amount of drug used is up to 10 fold lower than in HIPEC. The use of cytotoxic drugs poses an occupational risk for the operating room personnel. This study investigated the potential exposure of the medical staff by biomonitoring and surface contamination measurements, during a HIPEC procedure and a PIPAC procedure. Wipe samples were collected from various locations in operating rooms including gloves, hands, devices and floor. Urines samples were collected from 10 volunteers of the medical staff and from a control group. The platinum analysis was performed by inductively coupled plasma mass spectrometry. Significant contaminations were observed on the floor, gloves, shoes and devi...Continue Reading

Citations

Mar 7, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Marie PalaminiJean-François Bussières
Apr 9, 2020·Occupational Medicine·M WiszniewskaJ Walusiak-Skorupa
Jul 4, 2019·The Lancet Oncology·Mohammad AlyamiVahan Kepenekian
Nov 26, 2020·Plastic and Reconstructive Surgery·Wilmina N LandfordSheri Slezak
Sep 10, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Olivia SgarburaUNKNOWN ISSPP PIPAC study group
Nov 18, 2019·Journal of Pharmacological and Toxicological Methods·E RossignolC Bobin-Dubigeon
May 27, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Fanny RoussinGaëlle Maillan

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